Question

Place the label in the appropriate place to describe regulation of GPCR signaling by arrestin. A) Phosphorylatio n of the GPCR by beta ARK and PKA BBeta arrestin is recycled to traffic another GPCR to the ysosomes C) Once phosphorylated , the GPCR binds arrestin and is endocytosed D ) Gbeta and gamma subunits reruit beta ARK to the membrane

Answer 1

Answer:

Explanabion The above figwre Mepresents the basie scheme of B- ovreslin nega tie feedback and GPCR ( Grpkotein- oupled receptore) aindoytrais . agenist dimuletis the astivalion b the dissociatiom * Gproteins • Af Licaf, the of "GPCR leeding einto activated Q- subunit and B-Ydimee . G beta and expasve. amma subunits then receut befa ARK which alony with PKA, eauses fo the membreane phosphorylation of the GPCR. This leads to and kinding of the desensifixation B- axretin fo the activated, phosphorylated GPCR Binally, birding f axcatin loadh &ubsequent erdoeyforis reecepotde in the lysosome . he. 'GPCR, may signal % the also le reecycled to the plastha membrane . abuaq uenty mgyeled to Araffie B- arcestins another GPCR to the 'lysozome