Question

Would you expect ACE (angiotensin converting enzyme) inhibitors to increase or decrease urine output? Explain.

Answer 1

• Angiotensin converting enzyme inhibitors increases the urine output.
• ACE inhibitors decreases blood volume.

Mechanism.

• The drug taken ACE inhibitor is a antihypertensive drug.ACE inhibitor - angiotensin converting enzyme inhibitor.
• ACE is an enzyme produced in lungs that convert angiotensin I to angiotensin II.
• MEchanism of action of ACE inhibitor.
• ACE inhibitor act on Renin angiotensin aldosterone system(RAAS) .
• RAAS is a special mechanism that act on kidney to increase the body fluid and blood pressure.
• RAAS mainly involve reabsorption of Na+ and H2O from the distal tubule.
• Increased Na+ and H20 reabsorption result increase blood volume and blood pressure

RAAS mechanism is described below;

• Low blood volume and low blood pressure release Renin,
• Renin convert angiotensinogen to angiotensin I.
• Angiotensin I converted to Angiotensin II by ACE.
• Angiotensin II act on adrenal gland release aldosterone .
• Aldosterone cause Na+ and H2O reabsorption from distal tubule .
• Angiotensin II also act on blood vessel cause vasoconstriction result in increase blood pressure.
• ACE inhibitor inhibits AC enzyme, results in failure of formation of angiotensin II , results in low blood volume and low blood pressure.