Question

Ha uene et the mbrane tor uptake. What kind of structural features and binding would be reeded 7. Design a potential binding site for the following molecule, the testosterone hormone. Circle at least 3 sites on the molecule where non-covalent interactions can form, name the type of interaction for each site and indicate an amino acid whose side chain could form that type of interaction at that site. E Testosterone CH 0

Answer 1

Testosterone:

Testosterone is a potent Androgenic steroid and major product secreted by the leydig cells of the testis. It's production is stimulated by luteinizing hormone from the pituitary gland.

Potential binding site:

In males testosterone carried by SHBG, is ultimately converted to the active metabolite dihydro testosterone (DHT) by SRD5A( steroid 5 alpha reductase)

Non covalent interactions can form at hydrogen bonds ionic bonds and vanderwalls interactions and hydrophobic bonds.

Strongest non covalent interaction are hydrogen bond.

3 sites for non covalent interactions form are:

Type of interaction for each site:

1. Hydrogen bond

2. Vanderwall forces

3. Ionic bond

D- aspartic acid side chain could form that type of interaction at that site.