Question

Much effort has been directed toward determining the genes in which sequence variation contributes to the development of type 2 diabetes, a disease that results from a loss of sensitivity of cells to insulin. Approximately 800 genes have been implicated. Propose an explanation for this observation.

This is the only information I was given. :(

Answer 1

There is a link between the developing gene variations in type 2 diabetes patients’ associated with single nucleotide polymorphism (SNPs). It has illustrated that the signaling network pathways are triggered by insulin hormone associated with a higher number of signaling proteins. Therefore, several additional proteins are going to involve in the "termination" of signaling of insulin hormone. Finally gene variations in nearly 800 sequences with SNPs cause a defect in the coding for proteins essential for insulin signaling pathways (for example, receptor tyrosine kinases mediate insulin signaling) result in ending of "insulin hormone downstream events" that cause type-2 diabetes mellutus. Hence, it can be concluded that different gene defects cause gene variations that result in type 2 diabetes