2. Predict the product(s) of each of the reaction conditions below. Specify the substrate type (primary, secondary, or tertiary alkyl halide), nucleophile (strong or poor), and the solvent type (protic or aptrotic). Specify the type of reaction mechanism (SN1 or SN2), show the curved arrow mechanism and draw the products as 3D structures to illustrate stereochemistry.
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2. Predict the product(s) of each of the reaction conditions
below. Specify the substrate type (primary,...
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary,...
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary, or tertiary, Label the nucleophile as strong or weak. Decide whether an S2 or an Sol reaction occurs. Alter, show the mechanism and product or products. Indicate stereochemistry where appropriate. a. Reaction of 1-bromopropane and sodium methoxide in methanol + Na CH₂ CH OH b. Reaction of 2-bromopropane in ethanol Br + CH.CH, OH - c. Reaction of (R) 3-chloro-3-methylheptane in acetic acid CH3...
Please fill out the following table, indicating the category of reaction (Swi or Sm2) that will...
Please fill out the following table, indicating the category of reaction (Swi or Sm2) that will occur in each set of alkyl halides and nucleophiles. If no reaction occurs, write 'NR." Alkyl Halide Strong Nucleophile Weak Nucleophile SN2 SNZ SN2 SNI SNL SNU SNI SNI Methyl 10 2° 3° When determining which mechanism (Sw1 or S2) occurs, the following process is helpful: 1) Determine the substitution (methyl, 1º, 2º, or 3º) of the alkyl halide 2) Determine the strength of...
organic chemistry Substitution Problems 1. in each of the problems below, label the alkyl halide as...
organic chemistry
Substitution Problems 1. in each of the problems below, label the alkyl halide as primary secondary, or tertiary Label the nucleophile as strong or weak Decide whether an 5,2 or an 51 reaction occurs. After, show the mechanism and product or products, indicate stereochemistry where appropriate Reaction of 1-bromopropane and sodium methoxide in methanol + Na CH- CH,OH Reaction of bromopropane in ethanol CHCHH - Reaction of R)-chloromethylheptane in acetic acid + CH CH.COOH Reaction of the molecule...
3. a. List the and state if( ) (10 pts ca.) i. Nucleophile (strong/weak), Basicity (strong/weak)...
3. a. List the and state if( ) (10 pts ca.) i. Nucleophile (strong/weak), Basicity (strong/weak) ii. Substrate (1°/2°/3°) iii. Leaving group (good/poor) iv. Solvent (protic/aprotic) b. Label the mechanism for the reaction (S1/S2/E1/E2) c. Draw the mechanism for the reactions and predict the major product(s). Use proper stereochemistry where necessary d. State which is the rate determining step (RDS) e. Give a rate law for each reaction. Ex: Rate=K[ A B NaSCH CH2CN OH HI MeOH
Propose a mechanism from the reaction in the box NaOH H,CH2CH.CH DMF Use the reaction for...
Propose a mechanism from the reaction in the box
NaOH H,CH2CH.CH DMF Use the reaction for 28-32 28. What is the classification of the alkyl halide? a.) methyl b.) 1° c.) 2° d.) 30 29. Is the base strong or weak? a.) Strong b.) Weak 30. Is the solvent protic or aprotic? a.) Protic b.) Aprotic 31. According to the base and solvent, which substitution mechanism will the reaction undergo? a.) SNI b.) SN2 32. The stereochemistry of the reactant...
4. Considering the structure of the substrate, the nature of the nucleophile, and the solvent (written...
4. Considering the structure of the substrate, the nature of the nucleophile, and the solvent (written on the arrows), determine the type of mechanism (Sxl or Sx2) for every reaction. Predict the products and draw the mechanism. + KN. DMF a) (KN=N=N) 6 YOH + H-al water ethanol + CH3CH OH acetone Br + KI Br Br + DMSO DMSO CCB + KCN KSCH2CH3 D er + ken DMSO
12. For the following reaction, predict the product (s). Include appropriate stereochemistry No mechanism necessary. (8...
12. For the following reaction, predict the product (s). Include appropriate stereochemistry No mechanism necessary. (8 points) Also, indicate if the alkyl halide is R or S (2 points) OH Br
8. [18 pts) Provide the expected organic product(s) from each of the reactions below. Ignore the...
8. [18 pts) Provide the expected organic product(s) from each of the reactions below. Ignore the stereochemistry. No mechanism required! (3 points for each organic product, switching the major and minor will be penalized) a. Major: NaOCH; E2 Br b. Major Minor OH E2 Br 3 products in total CH,OH ΕΙ 6. 19 pts] For each of the following reactions, give the organic product(s), and include the stereochemistry when applicable. No mechanism required! (3 points for each organic product) a....
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary, or tertiary. Labe...
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary, or tertiary. Label the nucleophile as strong or weak. Decide whether an SN2 or an Sy1 reaction occurs. After, show the mechanism and product or products. Indicate stereochemistry where appropriate. a. Reaction of 1-bromopropane and sodium methoxide in methanol CH3 Na CH,Oн Br b. Reaction of 2-bromopropane in ethanol CH3CH2OH Br c. Reaction of (R) 3-chloro-3-methyl heptane in acetic acid Ci Cн CH,COOH но...
Dropdown Menus: 1. methyl, primary (unhindered), primary (hindered), secondary, tertiary 2. poor, weakly basic, strong...
Dropdown Menus:
1. methyl, primary (unhindered), primary (hindered), secondary,
tertiary
2. poor, weakly basic, strongly basic (hindered), strongly basic
(unhindered)
3. protic, aprotic
4. SN2, SN1, E1, E2, SN2 AND E2, SN1 AND E1, No Reaction
5. randomized, inverted, predictable but not inverted,
unchanged
6. a planar carbocation intermediate, backside attack transition
state, anti-periplanar transition state, other
CH3CH2ONa ??? CH3CH2OH Br OH OH OH De on an or rega ang Look at the given reaction and select the most appropriate...
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary, or tertiary, Label the nucleophile as strong or weak. Decide whether an S2 or an Sol reaction occurs. Alter, show the mechanism and product or products. Indicate stereochemistry where appropriate. a. Reaction of 1-bromopropane and sodium methoxide in methanol + Na CH₂ CH OH b. Reaction of 2-bromopropane in ethanol Br + CH.CH, OH - c. Reaction of (R) 3-chloro-3-methylheptane in acetic acid CH3...
Please fill out the following table, indicating the category of reaction (Swi or Sm2) that will occur in each set of alkyl halides and nucleophiles. If no reaction occurs, write 'NR." Alkyl Halide Strong Nucleophile Weak Nucleophile SN2 SNZ SN2 SNI SNL SNU SNI SNI Methyl 10 2° 3° When determining which mechanism (Sw1 or S2) occurs, the following process is helpful: 1) Determine the substitution (methyl, 1º, 2º, or 3º) of the alkyl halide 2) Determine the strength of...
organic chemistry
Substitution Problems 1. in each of the problems below, label the alkyl halide as primary secondary, or tertiary Label the nucleophile as strong or weak Decide whether an 5,2 or an 51 reaction occurs. After, show the mechanism and product or products, indicate stereochemistry where appropriate Reaction of 1-bromopropane and sodium methoxide in methanol + Na CH- CH,OH Reaction of bromopropane in ethanol CHCHH - Reaction of R)-chloromethylheptane in acetic acid + CH CH.COOH Reaction of the molecule...
3. a. List the and state if( ) (10 pts ca.) i. Nucleophile (strong/weak), Basicity (strong/weak) ii. Substrate (1°/2°/3°) iii. Leaving group (good/poor) iv. Solvent (protic/aprotic) b. Label the mechanism for the reaction (S1/S2/E1/E2) c. Draw the mechanism for the reactions and predict the major product(s). Use proper stereochemistry where necessary d. State which is the rate determining step (RDS) e. Give a rate law for each reaction. Ex: Rate=K[ A B NaSCH CH2CN OH HI MeOH
Propose a mechanism from the reaction in the box
NaOH H,CH2CH.CH DMF Use the reaction for 28-32 28. What is the classification of the alkyl halide? a.) methyl b.) 1° c.) 2° d.) 30 29. Is the base strong or weak? a.) Strong b.) Weak 30. Is the solvent protic or aprotic? a.) Protic b.) Aprotic 31. According to the base and solvent, which substitution mechanism will the reaction undergo? a.) SNI b.) SN2 32. The stereochemistry of the reactant...
4. Considering the structure of the substrate, the nature of the nucleophile, and the solvent (written on the arrows), determine the type of mechanism (Sxl or Sx2) for every reaction. Predict the products and draw the mechanism. + KN. DMF a) (KN=N=N) 6 YOH + H-al water ethanol + CH3CH OH acetone Br + KI Br Br + DMSO DMSO CCB + KCN KSCH2CH3 D er + ken DMSO
12. For the following reaction, predict the product (s). Include appropriate stereochemistry No mechanism necessary. (8 points) Also, indicate if the alkyl halide is R or S (2 points) OH Br
8. [18 pts) Provide the expected organic product(s) from each of the reactions below. Ignore the stereochemistry. No mechanism required! (3 points for each organic product, switching the major and minor will be penalized) a. Major: NaOCH; E2 Br b. Major Minor OH E2 Br 3 products in total CH,OH ΕΙ 6. 19 pts] For each of the following reactions, give the organic product(s), and include the stereochemistry when applicable. No mechanism required! (3 points for each organic product) a....
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary, or tertiary. Label the nucleophile as strong or weak. Decide whether an SN2 or an Sy1 reaction occurs. After, show the mechanism and product or products. Indicate stereochemistry where appropriate. a. Reaction of 1-bromopropane and sodium methoxide in methanol CH3 Na CH,Oн Br b. Reaction of 2-bromopropane in ethanol CH3CH2OH Br c. Reaction of (R) 3-chloro-3-methyl heptane in acetic acid Ci Cн CH,COOH но...
Dropdown Menus:
1. methyl, primary (unhindered), primary (hindered), secondary,
tertiary
2. poor, weakly basic, strongly basic (hindered), strongly basic
(unhindered)
3. protic, aprotic
4. SN2, SN1, E1, E2, SN2 AND E2, SN1 AND E1, No Reaction
5. randomized, inverted, predictable but not inverted,
unchanged
6. a planar carbocation intermediate, backside attack transition
state, anti-periplanar transition state, other
CH3CH2ONa ??? CH3CH2OH Br OH OH OH De on an or rega ang Look at the given reaction and select the most appropriate...
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