Question

1) XYZAL (levocetirizine dihydrochloride) is an orally active H1-receptor antagonist. XYZAL is indicated for the relief of symptoms associated with perennial allergic rhinitis in children 6 months to 2 years of age. Summary of Functional Groups Alchyde - - Alkyne -CC- a) (6 pts) Outline and name six functional groups present in this compound. Carboxylic ack Aroma Anomalie Ester b) (1 pt each + 1 pt) Place asterisk (*) next to chiral carbon(s). How many stereoisomers of this compound are possible? Alcohol -OH Amine Thiol - SH Amide c) (1 pt) How many carbons are present in this compound? → d) (1 pt) How many highly electronegative atoms (oxygen, nitrogen, chlorine atoms) are present in this compound? → e) (1 pts) How many charged groups would you expect to arise on this compound when in blood plasma at physiological pH of 7.40? Solubility - Solubility (in often measured in g/dL) describes ability of a given substance to dissolve (i.e. homogeneously disperse) in an another substance at a given temperature. When two liquids are involved, we refer to miscibility. To estimate solubility use following rules of thumbs 1) Computea ratio of carbon & sulfur to oxygen & nitrogen atoms. 2) For every -COO-.-NH, group, lower ration by 0.5 unit. 3) Interpret ratio using following table: ratio #CS) to (ON) - highly soluble (dozens old). 1 to 2 -soluble (grams/dL) - slightly soluble (miligrams/dL). to 5 -insoluble (less than micrograms/dL) 4 Check your estimate at http://pubchem.ncbinlm.nih.gov/ 1) (1 pts) Would you expect this compound to be highly soluble, soluble, slightly soluble, or insoluble in blood plasma? Support your answer with a clear argument. ОН Qonalar

Answer 1