4. Draw the mechanism for the conversion of 11 to 12.
5. What is the side product in the conversion of 12 to 13?
What is the role of the potassium tert-butoxide in the conversion of 16 to 6?
8. What oxidizing agent is used to convert 17 into 18?
9. In the conversion of 17 to 18 why does the acetal form between C2-C3 and C5-C6 rather than
C4-C5 or C3-C4?
1. What are 4Å molecular sieves? (Used in synthesis of 11) (Cite your source)
2. How was 11 purified?
3. What is the appearance of 14?
Homework Answers
There are many subparts in this questions. I am answering the first four only (in order of appearance) (Chegg Policy: 1 questions per post or 4 sub parts in 1 question)
ANSWER Q-4: Mechanism 11 to 12
This is reaction to protect the alcohol group transforming it into an ester. The general reaction is:
And the mechanism is
----------------------------------------------------------------------------
ANSWER Q-5: side product of 12 to 13
The conversion of 12 to 13 involves the cleavage of the acetal, this is done with HCl and CH3OH. This conversion genertaes a side product: acetone.
----------------------------------------------------------------------------
ANSWER Q-: role of potassium tert-butoxide in 16 to 6
The first step in conversion of 16 to 6 is a wittig reaction:
The tert-butoxide is used to transform the TMSCCCH2PPh3Br (3-(trimethylsilyl-2-propynyl)- triphenyl phosphonium bromide) into the ylide needed to wittig reaction. The tert-butoxide is a strong base and a weak nucleophile, this allows the formation of ylide
----------------------------------------------------------------------------
ANSWER Q-8: oxidazing agent in conversion 17 to 18
Conversion of 17 to 18 involves a first step of protection of OH group in the ring and the side chain by formation of an acetal. This cause the reduction of ring. Then, in the second step, the anomeric carbon is oxidized to a ketone. This reaction is done using PCC as oxidazing agent because this is useful to oxidized anomeric carbons:
Add Answer to:
4. Draw the mechanism for the conversion of 11 to 12.
5. What is the side...
9. In the conversion of 17 to 18 why does the acetal form between C2-C3 and...
9. In the conversion of 17 to 18 why does the acetal form
between C2-C3 and C5-C6 rather than
C4-C5 or C3-C4?
1. What are 4Å molecular sieves? (Used in synthesis of 11) (Cite
your source)
2. How was 11 purified?
3. What is the appearance of 14?
R. R. Gadikota et al. / Tetrahedron: Asymmetry 14 (2003) 737-742 739 오 Lo -. LOWOH a, b 10. 16 FO c - Lo e, f L Ho" OH TBDPSO | 01...
please need help with all the questions and ASAP, thank you 11. Please predict the principle...
please need help with all the questions and ASAP, thank you
11. Please predict the principle organic product of the following reactions, show stereochemistry where appropriate. Note that some reactions involve isotope-labeled compounds, in those cases the correct isotope must be used. (66') 1. LIAID 2. H,O (1) 18 1) THF (2). CH3Li + 2) HaO NaBH4 (3) CH3OD H2(excess)/Pt (4) d herd (5). - Mg Br D2O diethyl ether Br +Li (6) diethyl ether LICu(CH2CHs)2 Br (7). 1. diethyl...
PLEASE ANSWER ALL QUESTIONS. ROUND ANSWER TO THE FOURTH DECIMAL PLACE WHEN NEEDED Question 9 (1...
PLEASE ANSWER ALL QUESTIONS. ROUND ANSWER TO THE FOURTH DECIMAL
PLACE WHEN NEEDED
Question 9 (1 point) CZ CI 11c3 G C5 In the following circuit, C1=5.7 F, C2=2*5.7 F, C3=2*5.7 F, C4=2*11.4 F, and C5=3*11.4. Calculate the equivalent capacitance in the circuit. Your Answer: Answer units Question 10 (1 point) AR-C series circuit is connected to a 12 volt battery. Initially the capacitor has zero charge. Assume R= 17 12, C= 1,043 uF. When the circuit is closed, calculate...
4. The conversion of 5 to 6 is a reaction called “Sharpless Asymmetric dihydroxylation.” The reagents...
4. The conversion of 5 to 6 is a reaction called “Sharpless Asymmetric dihydroxylation.” The reagents listed for this are: AD-mix-B, CH3SO2NH2, t-BuOH, H20. a) What is compound(s) are described by “AD-mix-B?" (you can simply list them by name). c) What would be different if “AD-mix-a” was used? You don't need to provide a specific structure, but in general what would be different about the compound obtained? OH ОН ma MeO2C Butane-1,4-diol OH OP 2 3 Scheme 1. Sharpless asymmetric...
what is the mechanism of the Azo dye prepared using B4 Anilines NH2 LINH HOS SO,H...
what is the mechanism of the Azo dye prepared using B4
Anilines NH2 LINH HOS SO,H C Aniline-2-sulfonic acid HO,S A Sulfanilic acid B Aniline-3-sulfonic acid 1 1-Naphthol 2-Naphthol Phenols OH COH C3 3 Salicylic acid HO 4-Chloro-3-methylphenol A4 By C4 Figure 4.
A Kensington Company is planning production for the next 4 quarters. They want to minimize the...
A Kensington Company is planning production for the next 4 quarters. They want to minimize the cost of production. The production cost is stable but demand and production capacity vary from quarter to quarter. The maximum amount of inventory which can be held is 12,000 units and management wants to keep at least 3,000 units on hand. Quarterly inventory holding cost is 3% of the cost of production. The company estimates the number of units carried in inventory each month...
Thank you Please show all work Thanks 76.) [ 10 pts ] Consider the two S-boxes...
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please explain why the answers are what they are. thank you 18. Which one of these...
please explain why the answers are what they are.
thank you
18. Which one of these molecules does not contain any stereogenic centers? 19. How do the two chemical structures shown in the box below compare to one another? a) They represent the same molecule. b) They are isotopes. (c) They are constitutional isomers. d) They have different chemical formulas. 23. Based on structural characteristics, predict which of these substances has the lowest melting point @woo woo Dance CH 3....
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry....
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. My two target molecules are number 2 and number 12 in the last page. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the...
80 & NH 10 OH 11 12 og NH, Reaction 7: Reaction 8: Reaction 9: Reaction...
80 & NH 10 OH 11 12 og NH, Reaction 7: Reaction 8: Reaction 9: Reaction 10: Reaction 11: Reaction 12: Below is a list of reagents that will be used for the following question (reactions 7-12). L. 1.CH,Br 2. Ho P. Hz, Pd M. NaBH CHOH N 1 KCN 2. LAIH 3. H20 o. Brz o OH Q. NaOH, Br S. NH T. NHS U. 1. CHgMgBr 2. HO, mild H. NaĚH CN R. 1, KCN 2. HCI 3....
9. In the conversion of 17 to 18 why does the acetal form
between C2-C3 and C5-C6 rather than
C4-C5 or C3-C4?
1. What are 4Å molecular sieves? (Used in synthesis of 11) (Cite
your source)
2. How was 11 purified?
3. What is the appearance of 14?
R. R. Gadikota et al. / Tetrahedron: Asymmetry 14 (2003) 737-742 739 오 Lo -. LOWOH a, b 10. 16 FO c - Lo e, f L Ho" OH TBDPSO | 01...
please need help with all the questions and ASAP, thank you
11. Please predict the principle organic product of the following reactions, show stereochemistry where appropriate. Note that some reactions involve isotope-labeled compounds, in those cases the correct isotope must be used. (66') 1. LIAID 2. H,O (1) 18 1) THF (2). CH3Li + 2) HaO NaBH4 (3) CH3OD H2(excess)/Pt (4) d herd (5). - Mg Br D2O diethyl ether Br +Li (6) diethyl ether LICu(CH2CHs)2 Br (7). 1. diethyl...
PLEASE ANSWER ALL QUESTIONS. ROUND ANSWER TO THE FOURTH DECIMAL
PLACE WHEN NEEDED
Question 9 (1 point) CZ CI 11c3 G C5 In the following circuit, C1=5.7 F, C2=2*5.7 F, C3=2*5.7 F, C4=2*11.4 F, and C5=3*11.4. Calculate the equivalent capacitance in the circuit. Your Answer: Answer units Question 10 (1 point) AR-C series circuit is connected to a 12 volt battery. Initially the capacitor has zero charge. Assume R= 17 12, C= 1,043 uF. When the circuit is closed, calculate...
4. The conversion of 5 to 6 is a reaction called “Sharpless Asymmetric dihydroxylation.” The reagents listed for this are: AD-mix-B, CH3SO2NH2, t-BuOH, H20. a) What is compound(s) are described by “AD-mix-B?" (you can simply list them by name). c) What would be different if “AD-mix-a” was used? You don't need to provide a specific structure, but in general what would be different about the compound obtained? OH ОН ma MeO2C Butane-1,4-diol OH OP 2 3 Scheme 1. Sharpless asymmetric...
what is the mechanism of the Azo dye prepared using B4
Anilines NH2 LINH HOS SO,H C Aniline-2-sulfonic acid HO,S A Sulfanilic acid B Aniline-3-sulfonic acid 1 1-Naphthol 2-Naphthol Phenols OH COH C3 3 Salicylic acid HO 4-Chloro-3-methylphenol A4 By C4 Figure 4.
please explain why the answers are what they are.
thank you
18. Which one of these molecules does not contain any stereogenic centers? 19. How do the two chemical structures shown in the box below compare to one another? a) They represent the same molecule. b) They are isotopes. (c) They are constitutional isomers. d) They have different chemical formulas. 23. Based on structural characteristics, predict which of these substances has the lowest melting point @woo woo Dance CH 3....
Synthesis using Carbonyla-Substitution Chemistry Preamble This experiment involves the synthesis of target molecules using a-substitution chemistry. You are assigned two target molecules, one of which is best synthesized by an alkylation approach, while the other is best synthesized by an addition or condensation approach. My two target molecules are number 2 and number 12 in the last page. You must do the following: 1. Perform a retrosynthetic analysis on the two target molecules assigned to you. In each case the...
80 & NH 10 OH 11 12 og NH, Reaction 7: Reaction 8: Reaction 9: Reaction 10: Reaction 11: Reaction 12: Below is a list of reagents that will be used for the following question (reactions 7-12). L. 1.CH,Br 2. Ho P. Hz, Pd M. NaBH CHOH N 1 KCN 2. LAIH 3. H20 o. Brz o OH Q. NaOH, Br S. NH T. NHS U. 1. CHgMgBr 2. HO, mild H. NaĚH CN R. 1, KCN 2. HCI 3....
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