- Write a mechanism for the formation of N-Boc-protected dipeptide B
- Write a mechanism for the deprotection of Boc-protected dipeptide B to C.
Homework Answers
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Write a mechanism for the formation of
N-Boc-protected dipeptide B
Write a mechanism for the deprotection...
3) Amines are often protected with the tert-butyloxycarbonyl (BOC) group. Show the mechanism of formation of...
3) Amines are often protected with the tert-butyloxycarbonyl (BOC) group. Show the mechanism of formation of the BOC protected amine (a carbamate). Be sure to show all bonds formed/broken and include all intermediates including the appropriate formal charge. Na2CO3 + CO2 + NH NHBOC NaOC(CH3)3 leucine (BOC)20 Do you expect that the carbamate functional group is more or less reactive than an amide towards nucleophilic addition? Briefly explain your reasoning amide carbamate The BOC protecting group can be removed under...
b) Please write a reasonable electron pushing mechanism for the following (10 pts): NH N.
b) Please write a reasonable electron pushing mechanism for the following (10 pts): NH N.
b) Write the structure of the following compounds (Fischer projection): (D)-serine, (S)-methionine c) Write the structure...
b) Write the structure of the following compounds (Fischer projection): (D)-serine, (S)-methionine c) Write the structure of the following tripeptide: H-Ala-Pro-Phe-OH 2. Determine the N-terminal amino acid of the above tripeptide (H-Ala-Pro-Phe-OH) using the Sanger method (chemical equation). 3. Starting from alanine and glycine synthetize the glycyl-alanine (H-Ala-Gly-OH) dipeptide using mixed anhydride coupling method with Boc (amino) and Bn (carboxyl) protecting groups (reagents, reaction conditions, chemical equations). 4. Starting from the appropriate aldehyde synthetize alanine using the Strecker synthesis (reactions,...
Problem 5. Indicate according to which mechanism each reaction proceeds. If there are stable intermediates, the...
Problem 5. Indicate according to which mechanism each reaction proceeds. If there are stable intermediates, the reaction step leading to the final product is relevant. Choose from the following designations. [8 P Addition: Ar (electr. addn.), 1,2-AN. 1,4-AN (mucl. or conjug. addn.), syn-Addn., CA (cycloaddn.). Elimination: a E, E1, ElcB, E2, cyclo-E, Frag.(mentation). Substitution: Sx1, Ss2, SNAC (acyl subst. via Addn./Elim.); aromatic subst: SNAr (nucleoph.), SAr (electroph), Arvne. Rearrangement: Rearr. Radical reactions: Ag. Eg.Su- Reaction Mechanism a) HCI conc. (ag)...
4) Write the product, and draw a complete curved arrow mechanism for the reaction below. Include...
4) Write the product, and draw a complete curved arrow mechanism for the reaction below. Include the formation of all intermediates (10 points total) Product Mechanism 5) Name the following molecules (8 points total) a) NH b) 6) An amine A reacts with acetone in the presence of a trace of acid to give product B The 'H-NMR spectra of A and B are shown on page 5 as spectra A and B, respectively. ldentify A (amine)) and product B...
please explain How many "curved arrows are needed to describe the mechanism for formation of this...
please explain
How many "curved arrows are needed to describe the mechanism for formation of this intermediate? CH [D] 1 (EJ 2 IA 3 IC) 3 [B] 4 Explanation for your choice (3 pts) How can this transformation be accomplished? OH снен A. Br/CCL B. HYPd-C C.O.CH.OH G. HO/acid D. BryH.0 H. BẠH. E. Zn F.H.O I. H-0./NaOH J. CI HO K. NaH L. mCPBA M. HSO/A N. TsCpy O. KMnO/KOH TAJ H then G P. NaOH [B] O then...
b) CI d) He 2. Predict which of the following compounds are ionic and which are covalent, based on the location of...
b) CI d) He 2. Predict which of the following compounds are ionic and which are covalent, based on the location of their constituent atoms in the periodic table: (a) C1,CO (b) Mno (c) NCI, (d) CoBr (e) CaF (2) HI 3. Identify the more polar bond in each of the following pairs of bonds: (a) HF or HCI (b) NO or CO (C) SH or OH (d) PCI or SCI (e) CH or NH (1) SO or PO What...
2. Write the correct electron dot structure for the following covalent compounds: B. A. PCI N...
2. Write the correct electron dot structure for the following covalent compounds: B. A. PCI N F4 B. BF D. OF F. C. NO: NH, D. MgO H. C,,
Part A: Write an equation for the formation of NO(g) from its elements in their standard...
Part A:
Write an equation for the formation of NO(g) from its elements
in their standard states.
Express your answer as a chemical equation. Identify all of the
phases in your answer.
Part B:
Write an equation for the formation of BF3(g) from its elements
in their standard states.
Express your answer as a chemical equation. Identify all of the
phases in your answer.
Part C:
Write an equation for the formation of C6H6(l) from its elements
in their standard...
The product is the epoxide shown below. H3C b Write a mechanism for the reaction using...
The product is the epoxide shown below. H3C b Write a mechanism for the reaction using curved arrows to show electron reorganization. Arrow-pushing Instructions no-X HH :0: H₃C CH₃
3) Amines are often protected with the tert-butyloxycarbonyl (BOC) group. Show the mechanism of formation of the BOC protected amine (a carbamate). Be sure to show all bonds formed/broken and include all intermediates including the appropriate formal charge. Na2CO3 + CO2 + NH NHBOC NaOC(CH3)3 leucine (BOC)20 Do you expect that the carbamate functional group is more or less reactive than an amide towards nucleophilic addition? Briefly explain your reasoning amide carbamate The BOC protecting group can be removed under...
b) Please write a reasonable electron pushing mechanism for the following (10 pts): NH N.
b) Write the structure of the following compounds (Fischer projection): (D)-serine, (S)-methionine c) Write the structure of the following tripeptide: H-Ala-Pro-Phe-OH 2. Determine the N-terminal amino acid of the above tripeptide (H-Ala-Pro-Phe-OH) using the Sanger method (chemical equation). 3. Starting from alanine and glycine synthetize the glycyl-alanine (H-Ala-Gly-OH) dipeptide using mixed anhydride coupling method with Boc (amino) and Bn (carboxyl) protecting groups (reagents, reaction conditions, chemical equations). 4. Starting from the appropriate aldehyde synthetize alanine using the Strecker synthesis (reactions,...
Problem 5. Indicate according to which mechanism each reaction proceeds. If there are stable intermediates, the reaction step leading to the final product is relevant. Choose from the following designations. [8 P Addition: Ar (electr. addn.), 1,2-AN. 1,4-AN (mucl. or conjug. addn.), syn-Addn., CA (cycloaddn.). Elimination: a E, E1, ElcB, E2, cyclo-E, Frag.(mentation). Substitution: Sx1, Ss2, SNAC (acyl subst. via Addn./Elim.); aromatic subst: SNAr (nucleoph.), SAr (electroph), Arvne. Rearrangement: Rearr. Radical reactions: Ag. Eg.Su- Reaction Mechanism a) HCI conc. (ag)...
4) Write the product, and draw a complete curved arrow mechanism for the reaction below. Include the formation of all intermediates (10 points total) Product Mechanism 5) Name the following molecules (8 points total) a) NH b) 6) An amine A reacts with acetone in the presence of a trace of acid to give product B The 'H-NMR spectra of A and B are shown on page 5 as spectra A and B, respectively. ldentify A (amine)) and product B...
please explain
How many "curved arrows are needed to describe the mechanism for formation of this intermediate? CH [D] 1 (EJ 2 IA 3 IC) 3 [B] 4 Explanation for your choice (3 pts) How can this transformation be accomplished? OH снен A. Br/CCL B. HYPd-C C.O.CH.OH G. HO/acid D. BryH.0 H. BẠH. E. Zn F.H.O I. H-0./NaOH J. CI HO K. NaH L. mCPBA M. HSO/A N. TsCpy O. KMnO/KOH TAJ H then G P. NaOH [B] O then...
b) CI d) He 2. Predict which of the following compounds are ionic and which are covalent, based on the location of their constituent atoms in the periodic table: (a) C1,CO (b) Mno (c) NCI, (d) CoBr (e) CaF (2) HI 3. Identify the more polar bond in each of the following pairs of bonds: (a) HF or HCI (b) NO or CO (C) SH or OH (d) PCI or SCI (e) CH or NH (1) SO or PO What...
2. Write the correct electron dot structure for the following covalent compounds: B. A. PCI N F4 B. BF D. OF F. C. NO: NH, D. MgO H. C,,
Part A:
Write an equation for the formation of NO(g) from its elements
in their standard states.
Express your answer as a chemical equation. Identify all of the
phases in your answer.
Part B:
Write an equation for the formation of BF3(g) from its elements
in their standard states.
Express your answer as a chemical equation. Identify all of the
phases in your answer.
Part C:
Write an equation for the formation of C6H6(l) from its elements
in their standard...
The product is the epoxide shown below. H3C b Write a mechanism for the reaction using curved arrows to show electron reorganization. Arrow-pushing Instructions no-X HH :0: H₃C CH₃
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