Question

[References) Predict the major substitution products of the following reaction. CH3 H3C CH3OH H . • Use the wedge/hash bond tools to indicate stereochemistry where it exists. • If there is more than one major product possible, draw all of them. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. • Separate multiple products using the + sign from the drop-down menu.

Answer 1

Q predict the major Substitution products of the following Beaction hea uilcha CNBOH Hivy Ans 1 first draw the chair conformations cho eng [liz As the reaction center is Tetra substituted. Be substitution reaction will go through SN mechanism. so the intermediate will be the planar cation, as shown below.. M ong V CHzon is not strong Nucleophile it will attack on carbocation which will form en SNI reaction. & As the carbocation is planar both side attack is possible, but the still favoured conformation or product will be the one that places these two methyl group eguatoual & Methoxy group at axial because in methoxye the methyl group is removed somewhat from ring $ U as shown here below. partme

so the major product will the be the A where both methyl is eguatorial. & one at axial. Mon chon on A ona (M3 (SNI reaction Mo (A major + mea Ana enz (B) minor