A 1.25×10^-4 M solution of the anti-inflammatory drug naproxen has a pH = 4.2. Find the...
A 1.25×10^-4 M solution of the anti-inflammatory drug naproxen has a pH = 4.2. Find the Ka and pKa of naproxen.
Homework Answers
here the pH = 4.2
pH = -log[H+]
=> [H+] = 6.31*10-5 M
Naproxen is an carboxylic acid and it is taken as HA
HA -------------------> H+ + A-
I 0.000125 0 0
C -x +x +x
E (0.000125-x) x x
Ka = [H+][A-] / [HA]
Ka = (6.31*10-5 ) (6.31*10-5 ) / (0.000125-6.31*10-5)
Ka = 6.43*10-5
pKa = -log[Ka]
pKa = -log[6.43*10-5 ]
pKa = 4.1916
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