Which of the following sets of reagents and sequences of reactions can be used to complete...
LLLL MA 22. Which of the following sets of reagents and sequences of reactions can be used to complete the following synthesis? FI File -OH LEBY IEEE II EEEEEE B Eto COEL CELE EE LOW TE T BE NE A. (1) Dimethyl malonate, NaOEt; (2) 1,4-dibromobutane, (3) NaOEt, (4) H30", heat B. (1) Dimethyl malonate, NaOEt; (2) 1,3-dibromobutane, (3) NaOEt, (4) H30*, heat C. (1) Dimethyl malonate, NaOEt; (2) H:0", heat, (3) 1,4-dibromobutane, (4) NaOEt D. (1) Dimethyl malonate, NaOEt;...
le chatelier experimen Thursday). 1. What starting material and reagents are needed for the following multi-step synthesis (HINT: aldol reactions work best when the starting material can only form one enolate)? 5 он о D. NaOH, H2O, Heat F. HO E. NaOH, H2O G. LDA Starting Material: Reagents: 2. LDA is a strong, sterically hindered base and will form the enolate. Sodium hydride is a weak base and will form the _ - enolate. Kinetic enolates are the stable and...
4. Draw the products of the following sequences of reactions. 1) NaOET, HOE 1) NaOEt Eto OEt 2) H3O+ 2) Br | 1) LDA, -78°C 2) 0 H30+ heat H 3) NaOH, heat 1) LDA (1.1 equiv), -78°C, THE 2) CH3Br 1) CH3CH2MgBr 2) H30* H2, Pd-C LU H2SO4 NaOH, H2O 1) LDA, -78°C 2) HOE 3) H30+ 1) O3 2) CH2SCH3
3. Give the major organic product(s) of each of the following reactions or sequences of reactions. Br2 CH3COOH OH 1. Bry, PB 2. H2O CH, III 13, NaOH (excess) HC-C-C- CH H20 CH; 1.2 equiv. NaOet, EtOH VOE2.AAB O= OE: + (CH),CHCHCH,Br 1. NOE! EtOH 2.H20, heat
Identify reagents that can be used to achieve the following transformation: Question 21 Identify reagents that can be used to achieve the following transformation: OH OH x Incorrect. (1) Conc. H2S04, heat, 2) RCO3H, 3) H307 • 1) NaOet, 2) OsO4, NMO 1) NaOH, 2) RCO3H, 3) H307 • 1) Conc. H2SO4, heat, 2) OsO4, NMO
A) 1) NaOH 2) PhCH Br 3) NaOH Br 4) 5) H307, heat B) 1) NaOE 2) PhCH2Br 3) NaOET Br 5) H30-, heat C) 1) NaOET 2) Bromo benzene 3) NaOEt Br 4) Review of Skills - Skill Builder 21.05 Choose the correct order of reagents for performing the following transformation. 1) COH Eto OEU 2) 3) 4) 5)
4. Give the major organic product(s) for each of the following reactions or sequences of reactions. H Br 1. N.CN 2. NaOH,H,O, heat 3.H30 Ind o do CH,COOH 1. LiAlH, THF, heat 2.H,0 HO CH Br 1. NaCN, acetone 2.H30, heat h ome couco C:03, H30* он
Predict the products for the following reactions. Note – think about the base being used – is it catalytic? If so, can the product molecule ring-close? NaOEt OEt 1) Ph,CuLi, -78°C 2) H20 1) NaOEt EtO OEt 2) NaOH/H20 3) HСИН20 4) Heat 1) R2NH, H 2) H 3) Н,о" 1) R2NH, H* Ph 2) 3) Нзо* NaOEt OEt 1) Ph,CuLi, -78°C 2) H20 1) NaOEt EtO OEt 2) NaOH/H20 3) HСИН20 4) Heat 1) R2NH, H 2) H 3)...
A-C and bottom question In the following starting material(s), reagent(s) or product(s) are missing. Fill in the missing material. 1) [H30*), Brz 2) pyridine 1) Bra. PBrg 2) H20 1) Excess NaOH, Excess Bra 2) H30* NaOH Heat о Eto O Heat NaOET OEI 2) H30* DET f.and g. (In your answer include the temperature at which you would you run these reactions?)
(32 pts) Complete the following reaction sequences by drawing the major products or the reagents necessary to make them. Be sure to include stereochemistry when appropriate. 2. NaOEt 'Br DMF EtOH, Δ Br 2 Cl Cl Cl HO Br Cl Cl H2 (8) Lindlar's cat.