Question

By "form" for the iron, they are referring to its oxidation state.

- Iron overload is a medical condition where the body cannot cope with abnormally high levels of iron in the avstem. Chelation therapy by administering desferri- Oxamine, 7.31, is used to treat the problem. Suggest the origin of the name chelation therapy. What form should the iron be in for the therapy to be most effective? Suggest how the therapy works using com- pound 7.31; donor sites in the ligand are marked with red arrows and the OH groups can be deprotonated. CZ NH2 'N V OH 0 ОН Me N 0 (7.31)

Answer 1

Origin of Chelation therapy- In 1930's Ferdinand Munz, German chemist devloped ethylenediaminetetraacetic acid (EDTA). During World war II, the chemist learned that EDTA was particularly effective in treating lead poisioning as EDTA is chelating ligand which chelate the lead so from that chelation therapy name originated.

Iron(III) form like in ferritin is more effective in this therapy, 100 parts of weight of disferrioxamine can bind approximately 8 parts by weight of ferric iron.

Disferrioxamine is a iron chelatorhaving iron chelating activity. It binds with free iron in a stable complex, preventing it from chemical recations. It chelates the iron forming ferrioxiamine, a water soluble chelate excreted by the kidneys through urine and also some excreted in the feces.