Question

What reagent would best accomplish the following transformation? H3CO ل H3CO DA H2NNH2, KOH, H20 B. H2, Pd LiAIH4 D. Zn(Hg), HCI

Answer 1

CASES TA questioni- What reagent would best accomplish the following dreams foremation a TBY IT then uco e coer WS AS HANNH₂, KOH, H₂O BY H₂ lpd 7 LiAlHy Dr Zucto), Hel red un w Arsi- ro Ho HCO HOT For the above conversion 4 reagendy are suggested but the question is Onich oney perfect. & Day Zn(tg), Hel – reduction which is known as clemmemen rediction is not breeffered here as in this process Hel used. So there is a chance of preotonation of the oxygen atom of - OCH₃ group reather than the oxygen atom of the carbonyl group. As a result yield of the reaction decreases. 7 LiAlHe reduction of a ketone will generate a 20 alcohol but our product is not that. so it is not the preffered reagent!

I Help is wed as a reducing agent. then there is a chanco of reduction the annole moiety rather than the ketone. но Hz/PS, см, он. AZ HANNH₂ Kolt, 14, known as wolff kishiner reduction is the preffered reduction mode. under basic condition the reduction wler happened perfectly and we get the desired product. and mechanism of the reaction's as follows - NINTH og 1300-TL HONIN Hz Hoy le h H₂NNH2 tof 12 BLOG - 142 -HO N-H N= - gozel NEM He or - H2O - M2 le ore H2O 4 IT - ОН ate