Question

A close up of a receipt Description automatically generated 5'ATGATA CACCIA GGA ACT GTC AAC CCI IGT* TGI CACIGA AGA 3' If the base highlighted in bold and marked with an * were mutated to a guanine, what sort of mutation would this be? Silent mutation Missense mutation Nonsense mutation Deletion Insertion

Answer 1

1) In the given sequence if the T* is mutated to a Guanine the mutation obtained would be called as a missense mutation since codon TGT gives rise to amino acid Cysteine and mutating T with guanine (G) that gives codon TGG would give rise to amino acid Tryptophan.

2) In the given sequence if the T* is mutated to a Cytosine the mutation obtained would be called as a silent mutation since codon TGT gives rise to amino acid Cysteine and mutating T with cytosine (C) that gives codon TGC would give rise to same amino acid Cysteine.

3)In the given sequence if the T* is mutated to an Adenine the mutation obtained would be called as a nonsense mutation since codon TGT gives rise to amino acid Cysteine and mutating T with adenine (A) that gives a stop codon (opal).