If one (1) molecules of 3-phosphoglycerateate is oxidized via glycolysis, the PDC, and the CAC in a kidney cell, how many total protons are pumped across the inner mitochondrial membrane by the ETC?
1 molecule of 3 - phosphoglycerate is converted to 1 pyruvate molecule in glycolysis. 1 molecule of pyruvate will give rise to 1 NADH during processing in the Pyruvate Dehydrogenase Complex (PDC) and an acetyl Co- A. This acetyl Co - A coalesces with 1 molecule of oxaloacetate and joins in the Citric Acid Cycle. Here it releases 3 molecules of NADH.
Thus in total 1 molecule of 3 - phosphoglycerate is responsible for production of 4 molecules of NADH.
We know that when NADH donates a pair of electrons to the Electron Transport Chain, Complex I releases 4 protons, then complex II releases 4 protons and finally complex IV releases 2 protons. Thus a single NADH is responsible for pumping of 10 protons across the inner mitochondrial membrane by the ETC.
Thus 4 molecules of NADH will result in pumping of 40 protons in total .
If one (1) molecules of 3-phosphoglycerateate is oxidized via glycolysis, the PDC, and the CAC in...
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