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Question 2: Explain why recessive pathogenic mutations often segregate at higher frequencies than dominant pathogenic mutatio
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Ans: In some of the cases, the of the dominant pathogenic mutations for the cell or the organism may be too critical for the mutation to be transmitted to new born offspring. Heterozygous mutations of FGFR3 gene cause thanatophoric dysplasia, which is a serious bone disorder. New born offspring become affected and die at birth because they are unable to breathe.One more serious mutation are specific activating mutations in the G protein-coupled receptor encoded by GNAS complex locus (GNAS). The lithality rate is huge for dominant pathogenic mutations so the segregation frequency is lasser than the recessive pathogenic mutation.

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