Among African Americans today, the frequency of the sickle cell allele is about 4-5%. In indigenous...
Among African Americans today, the frequency of the sickle cell allele is about 4-5%. In indigenous peoples of tropical West Africa, the frequency is 2-4 times higher. What do you think accounts for this difference?
Homework Answers
Sickle cell anaemia is more common in africans because the
sickle-cell trait confers some
resistance to falciparum malaria during a critical period of early
childhood, favouring survival of the host and subsequent
transmission of the abnormal haemoglobin gene.
African Americans with SCD are less admixed (as a
result of interbreeding between populations or
species who have been reproductively isolated and genetically
differentiated) they must inherit two copies of the
sickle mutation that is more
common among African populations. Subjects with
higher levels of Caucasian admixture are less
likely to carry the sickle mutation and thus less
likely to pass it to their offspring.
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Among African Americans today, the frequency of the sickle cell
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Question 1:
Question 2:
You are a population geneticist interest in the frequency of the sickle-cell allele in a small town in Sudan. From hospital records you know that people in the previous generation had 4% incidence of sickle-cell anemia. Assuming Hardy-Weinberg equilibrium, what is the expected frequency of the sickle-cell allele in the current generation, and what is the predicted frequency of heterozygotes in the population? Consider a woman who suffers from Menkes Disease, an X-linked recessive disease. Her...
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