Question

Cyclosporine is a powerful immune suppressant drug given to organ transplant recipients to prevent immunological rejection of the organ. Cyclosporine works by inhibiting calcineurin. Which of the following events in the TCR signaling cascade will NOT occur in the presence of this drug?

A. NFAT will remain phosphorylated

B. CRAC channel will be open

C. LAT will be phosphorylated by ZAP70

D. AP1 will be activated

E. All of the above will occur in the presence of cyclosporine

Answer 1

Option(E) because calcenurin is only responsible for the dephosphorylation of NFAT where as pathways given in other options are not not affected by the calcineurin so they will not be affected by the cyclosporin as well.

complex Picha & DAG & -oke NEAT [calcinemmin A DE Cyclospoun AP-1 com TIL-2 NEAT Promoten IL-2