Question

1) For each pedigree below, what is the most probable mode of transmission ON O HO HO | OOOOO To 다 1000 . ●o 2) Color blindness is X-linked. If unaffected parents produce an affected child, which parent transmitted the color O blindness? D 3) Children with ALD (pedigree at the left) have progressive brain damage, adrenal failure, and eventual death, CTO adrenal failure, and ever CJ- Which of the following terms describes the disease-causing allele? a) pleiotropic b) dominant c) recessive d) polygenic 4) What is the most likely mode of transmission? 5) What is the genotype of the woman in the first generation?

Answer 1

ANSWERS: 1. (a). The most probable mode of Heansmission fore this pedigree is autosomal dominant since; Treait doesn't skip genreations The distribution of treait among sexes es - almost equal : • The trait is getting bransmitted by either sex amone (b). The most probable mode of treansmission fore this pedeprece es autosomal recessive because; • Trait doesn't occare in all generations • Mast offected individuals have unaffected parents. • An almost equal number of affected males - and females are produced . 2. In this case, the mothere must have freansmitted the colour- blindness to her som . Genotype of mother ☆ xx. Gentype of father » xy. Genotype of son » xey. • • xey

(s). The correct option is (a) ie plecotropie. Since the gene for ALD influences more than one seemingly uneelated traits, it can be best described as plecoleopy . 4. From the pedigree it can be inferred that, the disease is most likely inherited as X-linked recessive disorder, because ; • mast affected individuals are male. affected "individuals don't appear in all generations. (5). XAY xy Hence, the woman in the firest genereation must be a carrier of the disease, with genetype XAX , where XA allele responsible fore ALD x → normal allele.

(s). The correct option is (a) ie plecotropie. Since the gene for ALD influences more than one seemingly uneelated traits, it can be best described as plecoleopy . 4. From the pedigree it can be inferred that, the disease is most likely inherited as X-linked recessive disorder, because ; • mast affected individuals are male. affected "individuals don't appear in all generations. (5). XAY xy Hence, the woman in the firest genereation must be a carrier of the disease, with genetype XAX , where XA allele responsible fore ALD x → normal allele.