Question

(a) For each pedigree, indicate the most likely mode of inheritance (6 pts) B. (b) In pedigree B, circle all individuals who are heterozygous. (2 pts) OG 0 0 0 0 0 호 c GO GO CD p. | 8 日 ITE | ODDC D Choices: A. Y-linked, B. X-linked dominant C. recessive, D. Autosomal dominant, E. Autosomal recessive.

Answer 1

A. Most likely mode of inheritance = X-linked recessive
Reason: Affected progeny have unaffected parents = Recessive
Males are more affected than females = X-linked

B. Most likely mode of inheritance = Autosomal dominant
Reason: Affected progeny have at least one affected parent = Dominant
Males and females are equally affected = Autosomal

C. Most likely mode of inheritance = Autosomal Recessive
Reason: Affected progeny have unaffected parents = Recessive
Males and females are equally affected = Autosomal

D. Most likely mode of inheritance = Autosomal Recessive
Reason: Only males are affected and phenotype is inherited from father to son.

Heterozygotes in pedigree B = II-1, II-4, II-5, and III-7