Question

For the enhanceosome, binding sequences are on both strands of DNA. Why? The proteins of the enhanceosome on one strand have a regulatory function, whereas those on the other strand bend the DNA strand. The proteins on one side of the strand bind to GC rich regions and those on the other strand bind to AT rich regions. The proteins of the enhanceosome completely enclose the double helix and straightened the double helix. The proteins on one strand clear the nucleosomes from the double helix and this allows the true regulatory proteins to gain access to the strand on the same side oas the TAATA box.. The proteins of the enhanceosome bind the opposite strand 5 bp out of phase with those on the normal strands so they are all on the same side of the double helix. O Enhancesomes act in both directions along the strand. For enhanceosome to enhance you, they need to improve the front of you as well as the back of you. Duh. Question 15 (1 point) Saved (Multiselect) For locus switching of the MATa locus (to MATalpha): A. HMRa is up-regulated by MCM1 at the RE locus. B. HMRa is down-regulated by MCM1 and alpha2 at the RE locus. o C. HMLalpha is up-regulated by MCM1 at the RE locus. D. HMLalpha is down-regulated by MCM1 and alpha2 at the RE locus. E. MATa is cut by HO. F. MATalpha is cut by HO.

Answer 1

1. Option A -The proteins of the enhanceosome on one strand have a regulatory function, whereas those on the other strand bend the DNA strand.

2. Option B, D &E are correct.

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