Question

Amino acyl tRNA synthetases use editing sites to increase specificity of the synthetases for their cognate amino acids. What makes this "editing site" mechanism energy expensive?

Answer 1

Solution

aminoacyle tRNA synthetase is the enzyme which carry out charging of tRNA by addition of amino acid at active acylation site whereas wrong non cognate amino acid added at acylation site is removed at proofreading or editing site by hydrolytic removal of wrong amino acid from editing site.so it is energy expensive process.

all explained in given image.

solution - Aminoacyl tRNA synthetases are enzyme which adds. - cognate amino acid to its specific ERNA * synthetase has highly discriminating Amino acid sites. for Amino acid activation while the second site is called as poofreading or editing site. * The amino axlated tRNA can move the amino acid. between the activation site and the editing site . *if amino acid is fits properly and exactly in the editing site, then there is no need to remornino acid. by hp doilysis. aie. if amino add is smaller than pocket of editing site then hyydysis is required to remore wrong amino acid from editing site * so stimulation of ATP hy holysis in Hydolytic proof- reading is required to remoread non-cognate amino acids. from editing site & so for proofreading these is requirement of energy in the firm of ATP to remove your cognate amino acid. so it is enersy expensive proof reading process.