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- + Fit to page Page View 2). A blood DNA test for the cystic fibrosis allele is now available. You recommend to Lei that she

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Answer #1

CF is an autosomal recessive disease. Let us consider CF allele to be (c). So the disease would occur only if a person has genotype (cc). Test show that Lei is a carrier, i.e she must be heterozygous for the disease having Cc while Robert is not a carrier and does not have the disease. So Robert has CC

Male/Female C C
C CC (normal) CC(normal)
c Cc(normal carrier) Cc (normal carrier)

a. The Puneet square reveals that there is no chance of Lei and Robert's child having CF but the child has 50% chance of having CF.

b. The child has a 50% chance to be a carrier of CF or to not have CF allele at all. Even if the child is a carrier, there will be no manifestation of the disease and the child would be phenotypically normal.

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