Question

O pyruvate 1 pts Question 5 A patient presenting a variety of symptoms, including generalized fatigue and neurological impairment, is brought to the hospital, where tests reveal a severe GTP deficiency in the patient's liver. What is the likely cause of these symptoms? The patient's cells produce an overabundance of isocitrate, inhibiting GTP production. The patient's diet contains insufficient quantities of alpha-ketoglutarate. The patient has a mutated form of the enzyme that regulates succinate synthesis. A fat-rich diet caused cholesterol to bond to GTP-precursors, inhibiting GTP production. 1 pts Question 6

Answer 1

The correct option is 'C'. The case is related to kreb cycle. In 5^th step of citric acid cycle, there is substrate level phosphorylation. The details are given in diagram.

Solution: Acetyl conA citrate OAA Oxaloacefale Isolitrate Malate x-ketoglutarate fumatate - Enzyme (succirpyl - CGA- s (suctie fase) 7 e succinate e succinylcon I GTB GDP * During citric acid cycle ; GTP is formed at step where succinyl co-a į converted to succinate in presence of enzyme succinyl-CoA-synthetase via substrate level phosphorylation. So, if this step is blocked by any means; GTP will not be formed and found deficient. So, among given options; statement (3) is Correct.