Question

18 This pedigree above shows a family with members affected with a dominant neurodegenerative condition. Numbers represent th

0 0
Add a comment Improve this question Transcribed image text
Answer #1

In this family, the age of onset of the disease is decreasing with generations. Recent generations are expressing the condition at an earlier age. Such a phenomenon is called anticipation. Neurological disorders that are inherited , such as Huntingtons disease express such a phenomenon. The younger generations will have early onset of the disease and also the severity of the disease is much higher. Such a phenomenon is called Anticipation. This phenomenon is due to an unusual mutation called trinucleotide repeat expansion. Where 3 nucleotides are repeated number times causing the disease.

In the generation I, the onset is at 43. In present generation III, the onset is 22,18,40,39,25 years in different  offspring. This is Anticipation phenomenon in inheritance.

Add a comment
Know the answer?
Add Answer to:
18 This pedigree above shows a family with members affected with a dominant neurodegenerative condition. Numbers...
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions
  • A rare autosomal dominant condition affects the following family pedigree. What is the probability that the...

    A rare autosomal dominant condition affects the following family pedigree. What is the probability that the unborn child marked with the question mark is affected by the condition? Express the answer as a decimal fraction with two digits after the decimal point. Do not round the fraction. (i.e 1/3 = 0.33) Answer:

  • Use the pedigree shown below to answer the following questions. The pedigree is for a family...

    Use the pedigree shown below to answer the following questions. The pedigree is for a family in which dark-shaded symbols represent individuals with a hereditary form of early-onset colon cancer. Numbers under the symbols are the individual's age at the time of diagnosis. Crossed through symbols means the person is deceased. A) What is the genotype of the deceased individual in generation II? B) From this pedigree, how does this trait seem to be inherited? C) What are the possible...

  • 11. A rare autosomal dominant condition affects the following family pedigree

    11. A rare autosomal dominant condition affects the following family pedigree. What is the probability that the unborn child marked with the question mark is affected by the condition? Express the answer as a decimal fraction with two digits after the decimal point. Do not round the fraction. (.e 1/3 = 0.27) 12. Which of the following is not a necessary step in lytic bacteriophage infection cycle? Select one: a. Injection of the viral genome b. Viral protein is synthesized by the host cell c. The...

  • a.) Before individual II-2 had an affected son, this family believed the condition followed a dominant...

    a.) Before individual II-2 had an affected son, this family believed the condition followed a dominant mode of inheritance.  Why does the phenotype of III-1 support a recessive rather than a dominant mode of inheritance? b.) Could the mode of inheritance actually be dominant? Explain using appropriate genetic terms. c.) In order to better understand the risk of passing this condition on to additional offspring, individual II-2 sought genetic counseling which resulted in the drawing of this pedigree. This action makes...

  • Question 3 The following human pedigree shows a family affected by a specific disease. Assume that...

    Question 3 The following human pedigree shows a family affected by a specific disease. Assume that the individuals marked with an asterisk () do not carry any allele associated with the affected phenotype and that no other mutation spontaneously occurs. Also assume complete penetrance a) State the most likely mode of inheritance for this disease. Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive b) Write all possible genotypes of the following individuals in the pedigree. Use the uppercase...

  • Use the pedigree shown below to answer the following questions. The pedigree is for a family...

    Use the pedigree shown below to answer the following questions. The pedigree is for a family in which dark-shaded symbols represent individuals with a hereditary form of early-onset colon cancer. Numbers under the symbols are the individual's age at the time of diagnosis. Crossed through symbols means the person is deceased. A) What is the genotype of the deceased individual in generation 1 From this pedigree, how does this traseem to be writed? What are the possible genotypes for the...

  • Question 3 5 marks The following pedigree shows a family affected by a rare late-onset disease...

    Question 3 5 marks The following pedigree shows a family affected by a rare late-onset disease which is due to a mutation in a maternally imprinted gene. Individuals in generations I and II are all old enough to display the phenotype and all affected individuals are shown. Since this is a late onset disease, individuals in generation III are not yet old enough to display the phenotype, and therefore there are no affected individuals marked in this generation yet. The...

  • The following pedigree corresponds to a family affected by a rare autosomal recessive condition. What is...

    The following pedigree corresponds to a family affected by a rare autosomal recessive condition. What is the probability for the unborn child marked with "?"to be a carrier? Provide your answer as a decimal fraction up to the second digit after the period and do not round up or down. (i.e. if your result is 1/3 then write 0.33) 02 ? Answer:

  • A family tree of sorts is called a pedigree. The symbols used for a pedigree are:...

    A family tree of sorts is called a pedigree. The symbols used for a pedigree are: O female, unaffected Siblings are placed in birth order from left to right and are labeled with Arabic numerals. Each generation is labeled with a Roman numeral. Therefore the male exhbiting the female, affected male, unaffected trait in the pedigree below in the bottom, center would be identified as Il-4. male, affected -utington's Disease REVIEW – Reading a pedigree and dominant/recessive Inheritance. For questions...

  • The pedigree below that shows a family in which an autosomal recessive disorder is present. Family...

    The pedigree below that shows a family in which an autosomal recessive disorder is present. Family members 1-2 and II-2 are affected by the disorder and have the genotype dd. A pregnancy involving Il-4 has just undergone genetic testing for a VNTR that is linked to the disease gene. The VNTR has two alleles, V1 and V2. The gel electrophoresis patterns for each family member are shown, including the VNTR genotype for 1|-4. 2 - 2 3 4 = ?...

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT