Question

According to Figure 1A, the authors conclude that PolD1 interacts with gamma-TURO. Why is this figure more inconclusive than the authors suggest? Answe

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Answer 1

Here, normal rabbit IgG is used as the control immunoprecipitation. Thus in figure 1A, When it was probed with the PolD1 antibody, they got band both in control and the IP: GCP6 immunoprecipitation. So, concluding that PolD1 interacts with gamma TuRCs is inconclusive than the authors conclude