Question

For a protein such as ribonuclease, for the process of protein folding under native (non-denaturing) conditions,

Punfolded → Pfolded

Select the appropriate description for each of the thermodynamic parameters (for the folding reaction as shown above, from left to right):

What is the value of ∆G? What is the value of ∆Sconformational? The value of ∆S hydrophobic?
The choices for each question
A. positive, favorable for folding
B. positive, unfavorable for folding
C. negative, favorable for folding
D. negative, unfavorable for folding
E. No predictable sign

Answer 1

For folding of protein ,

∆G is negative.

Conformational entropy (-T∆S) is highly positive.

Hydrophobic effect (-T∆S) is negative.

Overall correct option is : (C) negative, favorable for folding