Question

co é o ó 7-1 A typical a:ß T cells undergoing development in the thymus successfully rearranges ß chain gene segments to code for a ß chain. Within the T cell, the ß chain will next interact with a pre-T alpha (pTa) protein to make a pre-T cell receptor interact with an alpha chain resulting in allelic exclusion interact with an alpha chain and undergo negative selection signal for the end of TDT expression during TCR formation co é All of the following statements regarding those strange semi-innate x:& T cells are correct except they are more abundant in tissue than in the circulation the d chain is the counterpart to the ß chain in a:ß T-cell receptors because it contains V, D, and J segments in the variable region they do not require CD4 or CD8 as co-receptors activation is not dependent on recognition of a peptide:MHC molecule complex expression of the X:8 TCR on the cell surface is not dependent on the CD3 complex. e.

Answer 1

7.1.a) after synthesis of beta chain, it will form pre TCR complex by binding with pre alpha chain. Allelic exclusion is seen in B cells.

This is not negative selection.

7.2)gamma Delta T cells goes with all statement other than expression of the gamma Delta TCR ON THE CEEL SURFACE IS NOT DEPENDENT ON THE CD3 COMPLEX..

BECAUSE IT IS REQUIRED FOR THE TCR RECEPTOR .ONLY ALPHA BETA AND GAMMA DELTA CAN BE INTERCHANGED TO MAKE ALPHA BETA OR GAMMA DELTA T CELL.

THEY DON'T REQUIRED CD4 AND CD8 CORECEPTOR IT IS RIGHT.