Question

Question 1: Everyone who has chronic myeloid leukemia (CML), a cell that makes blood cells, has a mutation where chromosome 22 has switched some DNA with chromosome 9. The switch causes there to be a gene fusion of two genes, BCR and ABLI. The ABL1 protein has many roles inside the cell, including promoting cell division. Normally, it is turned off until a certain signal from outside the cell activates it. However, when BCR is fused with ABLI, ABLI is able to be turned on all the time. A. Order the objects below from smallest to largest, with 1 being the smallest. (10pt) Eukaryotic cell Chromosome 22 Gene Genome Nucleotide Water molecule B. Based on the information above, is ABLI a tumor suppressor gene or a proto-oncogene? (roughly 2-3 sentences) C. Based on the information above, is the BCR-ABLI gene fusion mutation again-of- function mutation or a loss-of-function mutation? (roughly 2-3 sentences)

Answer 1

1.water molecule

2.nucleotide

3.gene

4.chromosome 22

5.genome

5.eukaryotic cell

B.ABL 1 is protooncogene because mutation of this leads to cancer. And it's function is to divide cells.

C.it is a gain of function mutation because normally the ABL1 gene is off but when it's is fused with BCR gene it becomes expressed.