Question

Will scanning a genome for ORFs facilitate the discovery of genes encoding non-codinng RNAs?

Answer 1

Answer- No, scanning a genome for open reading frames will not facilitate the discovery of genes encoding non-coding RNAs. A non coding RNA means a RNA molecule that will not be translated into a protein. That is why it is also called non coding RNA or sometimes also called junk RNA. They are mostly non functional and do not perform any translation into protein.

While we look into the complete genome of an organism, an open reading frame is the part of a reading frame that has the ability to be translated into a protein. So, while looking or scanning for only the ORFs in the genome and not the complete genome, the genes encoding for non coding RNA or the junk RNA will not be identified because that part of the genome will not be translated into a functional protein.

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