Question

2. (4 pts) A new drug targeting peptidoglycan synthesis has been invented, and its poteney is tested in the scheme below with a common gram positive pathogen in the lab, Staphylococus aureus Some inculum wa badded What is the minimal inhibitory concentration (MIC) of this drug toward S. aureus? When this drug is tested on a clinical S. aureus isolate from a patient, the MIC value for this drug is measured at >256 ug/ml. What does that tell you about the clinical isolate? Should the drug be used to treat the patient's infection? Negative Please explain. Growth No oth

Answer 1

In microbiology, the minimum inhibitory concentration (MIC) is the lowest concentration of a chemical, usually a drug, which prevents visible growth of a bacterium or bacteria. MIC depends on the microorganism, the affected human being (in vivo only), and the antibiotic itself.

The MIC of this drug towards Staph.aureus is 4 microgram/ml.

Minimum inhibitory concentration (MIC) can be determined by culturing microorganisms in liquid media or on plates of solid growth medium.A lower MIC value indicates that less drug is required for inhibiting growth of the organism; therefore, drugs with lower MIC scores are more effective antimicrobial agents.

MIC value of this drug is >256 microgram/ml, according to the diagram the MIC is 4 microgram/ml, which is less than 256 microgram/ml.

so this drug cannot be used to treat patient's infection.Because lowest concentration of an antibacterial agent necessary to inhibit visible growth. so 4 microgram/ml is sufficient to treat the patient's infection.