Aspirin (acetyl salicylic acid) is known as a nonsteroidal anti-inflammatory drug (NSAIDs). Which amino acid in...
Aspirin (acetyl salicylic acid) is known as a nonsteroidal anti-inflammatory drug (NSAIDs). Which amino acid in PGH synthase or COX is chemically altered by aspirin?
| Cysteine |
| Tyrosine |
| Threonine |
| Serine |
Homework Answers
Answer.. Serine
Explanation .. Aspirin has unique pharmacological effects, it acetylates selectively Ser-530 of prostaglandin endoperoxide (PGH) synthase-1. This causes inactivation of the cyclooxygenase activity of the enzyme, but does not appreciably affect its peroxidase activity.
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Aspirin (acetyl salicylic acid) is known as a nonsteroidal
anti-inflammatory drug (NSAIDs). Which amino acid in...
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) with the molecular system shown. Based on structural similarities,...
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID)
with the molecular system shown. Based on structural similarities,
which drugs is also a NSAID
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) with the molecular structure shown. H3C-CH-CH2-4 HyCaçH-CHI CH-COOH CH3 CHS Based on structural similarities, which drug is also a NSAID. ibuprofen CH2 NH2 CH3 amphetamine CHCOOH HC-0 naproxen a NSAID. ibupro 0 CH2 NH2 -CH CH3 amphetamine 0 CH-COOH H3C-0 naproxen 0 HO -C-CH₃ acetaminophen
I compounds are aspirin (acetyl salicylic acid) and methyl salicylate (i.e. alcohols, aldehydes, ketones, acids, esters,...
I compounds are aspirin (acetyl salicylic acid) and methyl salicylate (i.e. alcohols, aldehydes, ketones, acids, esters, amides, etc)? 5. Describe what physiological effects aspirin causes in the body, eg. regarding body temperature, pain, swelling and thrombosis (blood clotting). Does it inhibit an enzyme? If so, what enzyme does it inhibit and what substances are formed by that enzyme? [You should check the text book for information on aspirin's actions]. 6. Aspirin belongs to a specific class of drugs known as...
Which of the following amino acid residues are often involved in proton transfers in enzyme-catalyzed reactions?...
Which of the following amino acid residues are often involved in proton transfers in enzyme-catalyzed reactions? Select one: Histidine, aspartate, lysine, and serine Histidine, aspartate, glutamate, arginine, and lysine. Glutamine, asparagine, lysine, and tyrosine Histidine, aspartate, serine, and cysteine Serine, tyrosine, arginine, and cysteine
Though salicylic acid is the physiologically active chemical ingredient in aspirin, consumer aspirin formulations are actually...
Though salicylic acid is the physiologically active chemical ingredient in aspirin, consumer aspirin formulations are actually sold as a “derivatized” form of salicylic acid known as acetylsalicylic acid. Describe in detail the chemistry by which this aspirin formulation is synthesized and explain why we don’t just ingest aspirin composed of salicylic acid. After all, humans have been chewing on and making teas of willow bark to get the benefits of salicylic acid for thousands of years. What is the rationale?...
5. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation of various kinds,...
5. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation of various kinds, and is the active ingredient in the over-the-counter drug called Aleve. It operates by inhibiting the enzyme cyclooxygenase (COX) similarly to the more common ibuprofen, but does so with a stronger binding affinity The following pathway shows one example of a multistep synthesis that has been used to access naproxen. a Provide the missing intermediates, reagents, or major organic product in each box...
Quality Control for Pharmaceuticals A pharmaceutical company produces acetyl salicylic acid (aspirin) for use as one...
Quality Control for Pharmaceuticals A pharmaceutical company produces acetyl salicylic acid (aspirin) for use as one of the analgesics in a multi-component pain reliever. The synthesis of aspirin is shown below: | H COLH 0 0 O CH, COH ] Hyco CHE HC OH salicylic acid + acetic anhydride a cetyl salicylic acid + acetic acid Under acidic conditions, aspirin will decompose back to the original salicylic acid and acetic acid. O CH, COH COH . 110* + нс" о...
please help Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid,...
please help
Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
TABLE 5.1 PK values for amino acids 2.36 Amino acid Alanine Arginine Asparagine Aspartic acid Cysteine...
TABLE 5.1 PK values for amino acids 2.36 Amino acid Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine PK, PK₂ 2.34 9.69 2.17 9.04 2.02 8.80 1.88 9.60 1.96 10.28 2.19 9.67 2.17 9.13 2.34 9.60 1.82 9.17 9.60 9.60 2.18 8.95 2.28 1.83 9.13 1.99 10.60 2.219.15 2.09 9.10 2.83 9.39 2.20 9.11 2.32 9.62 2.36 9.21 5.56. Of the amino acids listed in Table...
1) Which reactant, salicylic acid or acetic anhydride, is in excess? Show your work. 2) If you we...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Pre-lab Questions: Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester...
Pre-lab Questions:
Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID)
with the molecular system shown. Based on structural similarities,
which drugs is also a NSAID
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) with the molecular structure shown. H3C-CH-CH2-4 HyCaçH-CHI CH-COOH CH3 CHS Based on structural similarities, which drug is also a NSAID. ibuprofen CH2 NH2 CH3 amphetamine CHCOOH HC-0 naproxen a NSAID. ibupro 0 CH2 NH2 -CH CH3 amphetamine 0 CH-COOH H3C-0 naproxen 0 HO -C-CH₃ acetaminophen
I compounds are aspirin (acetyl salicylic acid) and methyl salicylate (i.e. alcohols, aldehydes, ketones, acids, esters, amides, etc)? 5. Describe what physiological effects aspirin causes in the body, eg. regarding body temperature, pain, swelling and thrombosis (blood clotting). Does it inhibit an enzyme? If so, what enzyme does it inhibit and what substances are formed by that enzyme? [You should check the text book for information on aspirin's actions]. 6. Aspirin belongs to a specific class of drugs known as...
Which of the following amino acid residues are often involved in proton transfers in enzyme-catalyzed reactions? Select one: Histidine, aspartate, lysine, and serine Histidine, aspartate, glutamate, arginine, and lysine. Glutamine, asparagine, lysine, and tyrosine Histidine, aspartate, serine, and cysteine Serine, tyrosine, arginine, and cysteine
5. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation of various kinds, and is the active ingredient in the over-the-counter drug called Aleve. It operates by inhibiting the enzyme cyclooxygenase (COX) similarly to the more common ibuprofen, but does so with a stronger binding affinity The following pathway shows one example of a multistep synthesis that has been used to access naproxen. a Provide the missing intermediates, reagents, or major organic product in each box...
Quality Control for Pharmaceuticals A pharmaceutical company produces acetyl salicylic acid (aspirin) for use as one of the analgesics in a multi-component pain reliever. The synthesis of aspirin is shown below: | H COLH 0 0 O CH, COH ] Hyco CHE HC OH salicylic acid + acetic anhydride a cetyl salicylic acid + acetic acid Under acidic conditions, aspirin will decompose back to the original salicylic acid and acetic acid. O CH, COH COH . 110* + нс" о...
please help
Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
TABLE 5.1 PK values for amino acids 2.36 Amino acid Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine PK, PK₂ 2.34 9.69 2.17 9.04 2.02 8.80 1.88 9.60 1.96 10.28 2.19 9.67 2.17 9.13 2.34 9.60 1.82 9.17 9.60 9.60 2.18 8.95 2.28 1.83 9.13 1.99 10.60 2.219.15 2.09 9.10 2.83 9.39 2.20 9.11 2.32 9.62 2.36 9.21 5.56. Of the amino acids listed in Table...
1) Which reactant, salicylic acid or acetic anhydride, is in
excess? Show your work.
2) If you were to use 3.17 g of starting material, how much
product would you expect? Again, show your work.
3) Why is phosphoric acid added to the reaction?
4) A small amount of water is added at the end of the reaction
to react with the excess acetic anhydride. Show a balanced equation
for that reaction.
5) Explain the purpose of the FeCl3 test...
Pre-lab Questions:
Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
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