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Question 9 infected with nonresistant strains of the tuberculosis bacterium, antibiotics can relieve symptoms in a few weeks.
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If treatment with antibiotics is stopped and pathogenic bacteria are still present, it may obtain genetic basis for their persistency. The natural selection of bacteria enables cells carrying genes for antibiotic resistance to give rise to large population as a result of horizontal gene transfer and these genes can also spread to other species by transduction.

Antibiotic resistance is one of the major threats in which the bacteria develops a certain kind of resistance against the antibiotic. This antibiotic resistance is caused majorly due to mutation and hence the next generations of the bacteria become naturally resistant to antibiotics through natural selection. Hence, antibiotic resistance is something that evolves in a bacteria via natural selection which occurs due to random mutation at gene level. After the gene become evolved and bacteria become naturally resistant to the antibiotics, the gene can be transferred between individuals of same species via exchange of plasmid via horizontal gene transfer method. Via the horizontal gene transfer method, the antibiotic resistance gene can be transferred between members of same bacterial species with help of vectors. Once the species become resistant to antibiotic, they can spread it to different species as well with help of transduction in which virus called bacteriophage are able to carry genes which are from a certain bacterial species during infection and they can be incorporated into the DNA of another bacterial host. This way the antibiotic resistance is even conferred to other species of bacteria.

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