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A woman has a very rare disease which is not seen in any other family member (so disease is due to a spontaneous mutation). T
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Answer #1

Answer: Option 2 is correct
Explanation:
It is given that a female acquires an X-linked dominant mutation.
None of her parents carry the mutation.
So, she must be heterozygous for the dominant mutant allele.

XD = Dominant mutant allele
Xd = WT recessive allele

Genotype of the woman = XDXd
Genotype of the normal man = XdY

Parental cross: XDXd X XdY
Progeny: XDXd XDY XdXd XdY
The probability that her daughter is affected = 1/2
= 50%

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