Question

3) DNA polymerases that have an editing function bind to and encircle double-stranded DNA in their "palm" domain, and grip the double-stranded DNA tightly between their "thumb" and "fingers" domains. Since they can bind to any DNA double helix regardless of its sequence, which groove in DNA do you think they sample ("feel") for correct helix geometry? a) The minor groove b) The major groove c) Either of the above is equally probable

Answer 1

The palm region of DNA polymerase monitors the base pairing of most recently added nucleotides. This region of DNA polymerase forms hydrogen bonds with the base pairs in the minor groove of the newly synthesized DNA.

So option A ( minor groove) is correct.