Question

QUESTION 14 What molecules are often targeted in personalized cancer treatment? O receptor tyrosine kinases (RTK), because inhibiting DNA synthesis can slow down tumor growth receptor tyrosine kinases (RTK), because aberrant RTK signaling is often involved in unregulated cell division 20 points v Saved

Answer 1

14) Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assortment of human diseases, most notably, cancers. Recent large-scale genomic studies have revealed the presence of various alterations in the genes encoding RTKs such as EGFR, HER2/ErbB2, and MET, amongst many others. Abnormal RTK activation in human cancers is mediated by four principal mechanisms: gain-of-function mutations, genomic amplification, chromosomal rearrangements, and / or autocrine activation. In this manuscript, we review the processes whereby RTKs are activated under normal physiological conditions and discuss several mechanisms whereby RTKs can be aberrantly activated in human cancers. Understanding of these mechanisms has important implications for selection of anti-cancer therapies.

15) option 3 will be the correct answe