Homework Answers
Amswer:- Correct answer is D. as shown in below figure, HMG-CoA in presence of HMG-CoA reductase gives mevalonate as shown below
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In the reaction below HMG-CoA it is converted to mevalonate. What is the structure of mevalonate...
Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by...
Statin drugs, like Mevacor (lovastatin) and Lipitor (atorvastatin), act as competitive inhibitors of HMG-CoA reductase by mimicking the structure of mevalonate. However, it is not this inhibition that directly lowers cholesterol levels in the blood. What enzymatic reaction does HMG CoA-reductase catalyze? What is important about this step of cholesterol synthesis? How can statins mechanistically cause a decrease in LDL cholesterol in the blood if it is not a direct effect of decreased cellular cholesterol synthesis?
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characteri...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25 C, 30°C, and 37 C yielded dissociation constants (K.) of 2.5 x 10" М, 1.5 x 10", and 1.0 x 103 M, respectively, for the HMG-CoA reductase-inhibitor complex. a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizin...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25°C, 30°C, and 37°C yielded dissociation constants (Ks) of 2.5 x 10* M, 1.5 x 10*, and 1.0 x 10* M, respectively, for the HMG- CoA reductase-inhibitor complex a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel or...
art. VUL VE Select the partial mechanism below that correctly shows how pyruvate and acetyl CoA...
art. VUL VE Select the partial mechanism below that correctly shows how pyruvate and acetyl CoA are joined together in this reaction. I . LOON ONO SCOA SCOA Com AN O. -он -O SCOA To 22 SCOA noints oo -ОН H- SCOA SCOA -
SERBP, SCAP, Insig and Sec are proteins associated with regulating the synthesis of HMG-CoA reductase and...
SERBP, SCAP, Insig and Sec are proteins associated with regulating the synthesis of HMG-CoA reductase and other enzymes of cholesterol synthesis and uptake. What compounds bind to SCAP and Insig to down-regulate HMG- CoA reductase and cholesterol synthesis? A. ammonia and urea, B. glutamate and glutamine, OC. sterols and oxysterols, OD IMP and OMP, O E. all of the above, OF none of the above, QUESTION 15 The synthesis of which of the following compounds requires the most ATP and...
not sure about reaction 3 and 4 acetyl-CoA COA The reactions of the citric acid cycle...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
4. During the last step of the β-oxidation pathway for fatty acids, the intermediate below is con...
Solve all
4. During the last step of the β-oxidation pathway for fatty acids, the intermediate below is converted to CH3 (CH2) 12ČCH2C-SCoA a. CH3 (CH2) 12C00H + CoA b. 2 CH3C-SCOA CH3 (CH2) 126CH2CHsCH3C-SCoA d. 5. The intermediate below is produced during the fatty acid synthesis pathway. The next reaction of the pathway at the double bond, involves which type of reaction? CH3 (CH2 ) 12CH=CHCH2-ACP -CH2CH2OH- d. none of the above 6. The product of the first step...
what is the major product for the reaction below? What is the major product for the...
what is the major product for the reaction below?
What is the major product for the reaction below? KOCH HOCH 3, Heat Br с. осн, Select one: a. structure B O 0 b. structure A c. None of the choices d. structure C
Given the reaction below, answer the following questions. COA ATP AMP+PP tu. R 0 R SCOA...
Given the reaction below, answer the following questions. COA ATP AMP+PP tu. R 0 R SCOA 1. Name the enzyme that catalyzes this reaction. (2 pts.) 2. What is the common name for the lipid on the left, if it had eighteen carbons? (i.e. how did we refer to it in class?) (2 pts.) 3. If it was a 18:0 fatty acid, calculate the following upon its complete oxidation. • # of total FADH2 made (1 pt.) - # of...
Bromobenzene is converted to a compound with a molecular formula c7h7br in the reaction scheme below....
Bromobenzene is converted to a compound with a molecular formula
c7h7br in the reaction scheme below. Draw the structures of the
product and the two intermediates, and identify the reagents in
each of the three steps.
Bromobenzene is converted to a compound with a molecular formula c7h7br in the reaction scheme below. Draw the structures of the product and the two intermediates, and identify the reagents in each of the three steps.
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25 C, 30°C, and 37 C yielded dissociation constants (K.) of 2.5 x 10" М, 1.5 x 10", and 1.0 x 103 M, respectively, for the HMG-CoA reductase-inhibitor complex. a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel...
HMG-CoA reductase, a critical enzyme in cholesterol synthesis is the target or statin inhibitors. You are characterizing a possible new inhibitor and want to determine its mode of binding to HMG-CoA reductase. Equilibrium dialysis measurements at 25°C, 30°C, and 37°C yielded dissociation constants (Ks) of 2.5 x 10* M, 1.5 x 10*, and 1.0 x 10* M, respectively, for the HMG- CoA reductase-inhibitor complex a. Is the binding becoming better or worse with increasing temperature? Explain. b. Using Excel or...
art. VUL VE Select the partial mechanism below that correctly shows how pyruvate and acetyl CoA are joined together in this reaction. I . LOON ONO SCOA SCOA Com AN O. -он -O SCOA To 22 SCOA noints oo -ОН H- SCOA SCOA -
SERBP, SCAP, Insig and Sec are proteins associated with regulating the synthesis of HMG-CoA reductase and other enzymes of cholesterol synthesis and uptake. What compounds bind to SCAP and Insig to down-regulate HMG- CoA reductase and cholesterol synthesis? A. ammonia and urea, B. glutamate and glutamine, OC. sterols and oxysterols, OD IMP and OMP, O E. all of the above, OF none of the above, QUESTION 15 The synthesis of which of the following compounds requires the most ATP and...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
Solve all
4. During the last step of the β-oxidation pathway for fatty acids, the intermediate below is converted to CH3 (CH2) 12ČCH2C-SCoA a. CH3 (CH2) 12C00H + CoA b. 2 CH3C-SCOA CH3 (CH2) 126CH2CHsCH3C-SCoA d. 5. The intermediate below is produced during the fatty acid synthesis pathway. The next reaction of the pathway at the double bond, involves which type of reaction? CH3 (CH2 ) 12CH=CHCH2-ACP -CH2CH2OH- d. none of the above 6. The product of the first step...
what is the major product for the reaction below?
What is the major product for the reaction below? KOCH HOCH 3, Heat Br с. осн, Select one: a. structure B O 0 b. structure A c. None of the choices d. structure C
Given the reaction below, answer the following questions. COA ATP AMP+PP tu. R 0 R SCOA 1. Name the enzyme that catalyzes this reaction. (2 pts.) 2. What is the common name for the lipid on the left, if it had eighteen carbons? (i.e. how did we refer to it in class?) (2 pts.) 3. If it was a 18:0 fatty acid, calculate the following upon its complete oxidation. • # of total FADH2 made (1 pt.) - # of...
Bromobenzene is converted to a compound with a molecular formula
c7h7br in the reaction scheme below. Draw the structures of the
product and the two intermediates, and identify the reagents in
each of the three steps.
Bromobenzene is converted to a compound with a molecular formula c7h7br in the reaction scheme below. Draw the structures of the product and the two intermediates, and identify the reagents in each of the three steps.
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