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Use a dynamic programming table to align TTGGATA and TGGATCATA using the local alignment method (Smith...

Use a dynamic programming table to align TTGGATA and TGGATCATA using the local alignment method (Smith and Waterman) with the following scoring scheme: gap: -5; mismatch: -3; match: +3.

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This refers to find the arrangement with the most positive value following such scheme. This means a match (same nucleotide in the same position) is the main thing to seek, if not posible then go to mismatchs (different nucleotides in the same position), and the least desired is a gap (a nucleotide and a gap in the same position). Biologically, this means substitutions are more facored than indel mutations. The alignment would be:

TTGGATA___

_TGGATCATA 5 matches (15), 1 mismatch (-3), and 0 gaps, a final value of 12

As we have 5 matches (15), 1 mismatch (-3), and 0 gaps, for a total value of 12. This was made naked eye, but now look at the result of a dynamic program as it is asked:

Alignment of two DNA sequences TTGGATA--- 10 - TGGATCATA 10 Sequence 1 TTGGATA- Sequence 2 -TGGATCATA Computed in 0 seconds

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