Question

1. Use the BLOSUM substitution matrix to compute the sum of the substitution scores (Sij) and the overall likelihood ratio (L) of the following short alignments:

The substitution score is defined in terms of the logarithm of the substitution likelihood. Thus, Sij = 2xlog2Lij.   By rearrangement Lij = 2Sij/2

  -1-1 OVOU OWN IDMOZO>onn 3ܬ ܚ ܝܝ ܘܪܚܚܬ 10-14 30-2-20 3-10-2-20 - 11 -1 -1 -2 -1 1 E -4 0 -1 -1 -1-2 0 2 -3 0-1-1-1- 2002 -3 0

a. PADKTN

PEEKSA

b. KFLASV

ATWDPE

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Answer #1

Aus :- We use s=2 log, (L); Liz ; L:2 (8/2) as Sequence :PADKIN Sequence : PEEKSA Surore ;- (7) + (-1)+(2)+(5)+(1) +(2) Sum o

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