Explain in detail why viruses often use frame shifting while translating viral mRNAs
Explain in detail why viruses often use frame shifting while translating viral mRNAs
Homework Answers
Ribosomal Frameshifting
ribosomal frameshifting is a tightly controlled, programmed strategy used by some viruses to produce different proteins encoded by two or more overlapping open reading frames . Ordinarily, ribosomes function to maintain the reading frame of the mRNA sequence being translated. However, some viral mRNAs carry specific sequence information and structural elements in their mRNA molecules that cause ribosomes to slip, and then readjust the reading frame. The frameshift results from a change in the reading frame by one or more bases in either the 5′ (−1) or 3′ (+1) directions during translation. This ribosomal frameshift enables viruses to encode more proteins in spite of their small size.
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Explain in detail why viruses often use frame shifting while
translating viral mRNAs
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