Question

1. eIF4G is the cap-binding protein

true or false

2. Co-immunoprecipitation refers to a technique that allows researchers to investigate protein interactions

true or false

3. the rare single nucleotide polymorphism found in some Autistic patients result in

a) A gain of function allele

b) A dominant-negative

c) A hypomorph

d) A null allele

5. Which of the following statements is true regarding the function of 4EGI-1?

A) It disrupts the interaction of eIF4E with elF4G, thereby preventing translocation of the ribosome to the next codon

B) It disrupts the interaction of eIF4E with elF4G causing mRNA degradation

c) It disrupts the interaction of eIF4E with elF4G, preventing the closed loop conformation from forming and therefore inhibits translation initiation

d) It disrupts the interaction of eIF4E with elF4G, allowing the closed loop conformation to form and therefore promotes translation initiation

Answer 1

1. True - elF4G is the cap-binding protien.

2. True- Co-immunoprecipitation refers to a technique that allows researchers to investigate protien interactions.

3. Answer : a) A gain of function allele

4. Answer : b) it disrupts the interaction of elF4E with elF4G causing mRNA degradation