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1. Which of the following statements are true regarding neuronal morphology of elF4E Tg mice? elF4E Tg mice display a decreas

1. Which of the following statements is true regarding the function of 4EGI-1? It disrupts the interaction of elF4E with elF4

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Answer #1

1. eIF4E Tg mice display an increase in dendritic spine number but the size of individual spine is smaller

2. It disrupts the interaction of eIF4E with eIF4G, preventing the closed loop conformation from forming and therefore inhibits translation initiation

Note: The second option is correct specifically because 4EGI-1 inhibits the cap-dependant translation initiation.

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