Question

use the pathway below for 6(a,b,c)

6. (10 points) Below is the data for en activity. 210 activity 0.0407 0.035- 0.030 0.025- 1/(u/min) 0.020- 0.015- 0.010- 0.005- LOOOLO- -0.0875 -0.0750- -0.0625- oosoo- -0.0375- -0.0250- -0.0125 N 0.0000 0.0125- 0.0250- 0.0375 0.0500- 0.0625- 0.0875- 0.1000- 0.1125- 0.1250- 0.1375 0.1500- 0.1625- 0.1750- 0.1875- 0.2000- 0.2125- 0.2250- 0.2375- 30.0750- A. Interpret the graph and determine Ky and Vw Show all calculations. (4 points) B. One side effect of a commonly prescribed medication is a 50% decrease in enzyme concentration of co! Predict the numerical value of the V if a person would take this medication. Show your math and/or explain your rationale. Draw a new line on the graph that would correspond to the kinetics of a person taking this medication. (4 points) C. Predict how this medication would affect the overall health of the individual. Why? (2 points)

Answer 1

V mani. A. Following is a linewed wer graph for I (1-axis) Versus is (x-axis). In this graph, Intercept at Y-axis = 1 Therefore, t o the point touching the x-axis, approximately at middle " between the origin and 0.005. I = half of 0.005 vhar = 4*0.005 = 0.0025 Vman V man o Umare = 0.0025 Umarc = 400 MM/min.

УК أبر داد 1. Similarly, intercept on x-axis = 1 ] The intercept Poun is closer to -0.0125, therefore can be approximat to be =-0.0175 +=+0.0175 km odorar = 57.142.4M Km 16) 50% decrease in enzyme concentration i.e [Ex] We know ; Vman. = keat [Ex] with 50% decrease in [Et] ; Umana keat [0.5 Et] Umax' = 0.5 keat [Et] uman' = 0.5 man

As Vmax = 400 So, Vmax' = 0,5 x 400 = 200 Therefore, I = 1 = 0.005 1/um/min) 200 0 0 l 0 5700 - -0.0125 0.0000 0.01251 tostooo Ум м Те 4 <p4 vоu° Р ред. А.; ? (Kintezlept passing through 0.005.) (c) the individual would lack hair after taking this medication. because the penzyme concentration is decreased, the product will be produced in less amount, hence this hormone (the product) will stimulate less hair follicles, hence person lacking mir.