Question

How many NET ATPs would theoretically need to be used to store excess glucose as laurate (C12:0) (i.e., catabolize the glucose to acetyl-CoA and then anabolize to laurate)?  Since there are 12 carbons in laurate and each glucose can be converted to two acetyl-CoAs, assume that you'll begin with 3 glucoses.  Also, assume you already have sufficient oxaloacetate in the mitochondria to pair with the acetyl-CoA.  Show the basic outline of the process.  Indicate where each ATP, NADH, etc. is made or used.  (For simplicity, assume that NADPH is equivalent to NADH with respect to ATPs made in oxidative phosphorylation.)  When you're done, compare the ATP investment of fatty acid synthesis and comment on the efficiency of storage.

Answer 1

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o For lausate syntheses (612:0) autyl coor required which is formed by n oxidation of glucose. so total Acetyl wa required for formation of laufale care 6 noluk 20 x 6= 124 Auctyl con lausate & molecule of glucose release 2 aclyt a So for 6 alchyle con how many genose molecule required a 2 Acetyl con produced by & molecule of glucose 6 " " " u / x6 = 3 nolunt of gourse with release of total a NADAX 3 and 2003 so total 6NADE & GATP as out pet g 3 und & glycolysis. Further, Acetyl LWA converted to balenogl of which required APP Acetyl LOA + SATB - 51 malunghwa & Acutzt we & Acetyl was 128 Causati su Also, faty and synthase required to add acasbes to existing malonge wa to 4c so, for formation of the total sound of Fary and Synthase pathing goes on which also required NADPH Alsoane ofensgg so, sin a round of tary acid & you thase required 2 NADPD so for 5 round required 8422/ONADPI - so tatal energy required for lausats formation will be 5 ATP & IONADPA, And 10 NADP on oxidation form 24ATP/10 = 2005 so total investment is 35ATP for lausate formation While gain of ATP in glyrolysis was 2 and NADH was also a NADU guill release energy in form of APP=2x2.5=5AT. so rotal gain of ATP fron glipolysis = 245 27 Aro So, over all energy cost for lausate formation will be required (required ATP- gain ATP) = (35-7)= (28 ATP] is requial

Hope it's clear..thanks