Question

Question 14 2.5 pts A. Use several sentences to describe Ca2+-based mechanisms underlying neurotransmitter release. B. Assume you are recording from the squid giant synapse and are able to stimulate the presynaptic neuron and record the response in the postsynaptic neuron. Describe a set of experiments (and their results) to demonstrate that Ca2is both necessary and sufficient for neurotransmitter release. State which experiment you describe shows necessity and which shows sufficiency. Use several paragraphs to discuss your proposed experiments, what they show, and how you interpret them. 1 0 A A = = = x = B - I = = VX Ge v x 12pt HTML Editora = - Paragraph N

Answer 1

Ans. 1

voltage-gated calcium channel is the main focus for the release of neurotransmitter molecule and how they get out from synaptic vesicles in the axon terminal and crosses the synaptic cleft to bind the synaptic receptor. Firstly action potential will change membrane potential and this causes, the opening of a calcium ion channel. As a result, Ca ion will gradually enter inside the axon terminal. Over here, a reaction happens with presynaptic protein meanwhile membrane fuses and hence neurotransmitter molecules exit the axon terminal also flow out in the synaptic cleft. now it can easily bind to receptor of postsynaptic membrane. the flow of neurotransmitters and the amount of calcium enters inside the axon terminal both truly depend on the frequency of action potential.