Question

piosynthetic pathway is shown with 3-phosphoglycerate as the starting point. Fill out all of the missing factors 0- a NSNo methylene NADH to Keto to lutaras glutamate glutamate glitter THE кон -OOC NH, + H2O 000 Oooo- glycine 3-Phospho- glycerate Hoo- 3-phospho "serine *HAN COO serine 3-phosphohydroxy pyravate * 2. There are three metabolites produced through this pathway that are important for the cell. Two of them are amino acids (identify the amino acids by name). Discuss the role of the third significant product in metabolism.

Answer 1

1)3-phosphoglycerate>> 3-phosphohydroxypyruvate >>3-phospho L-serine- >>L-serine- >>Glycine

GAP 1,3 BPG 3PG 3 -Phosphoglycerine 2PG 3-Phospho hydroxy pyruvate PEP Phospho serine Glysine (Gly) Serine (Ser) ACCOA COA-SH O-Acetyl serine HS Cystein (Cys)

  THE WHOLE PATHWAY OF 3-PHOSPHOGLYCERATE

3-phosphoglycerate NAD+ Phosphoglycerate dehydrogenase (PHGDH) NADH + H+ 3-phosphohydroxypyruvate L-glutamate Phosphoserine aminotransferase 1 (phosphoserine transaminase) (PSAT1) I 2-oxoglutarate 3-phospho-L-serine H2O Phosphoserine phosphatase (PSPH) L-serine

SERINE SYNTHESIS

2)Amino acids produced are Serine and Glycine.And the third significant product is Cysteine,which is also an aminoacid with highly reactive sulfhydrl group.

The human body uses cysteine to produce the antioxidant glutathione, as well as the amino acid taurine. The body can also convert cysteine into glucose for a source of energy. Cysteine also plays a role in the communication between immune system cells

. CYSTEINE SYNTHESIS

+ acetyl-CoA + H2S or thiosulfate HOY OH CysE wh2 (serine acetyltransferase) NH2 YOH - HS Y OH CysK/CysM (O-acetylserine sulfhydrylase) N 2 O-acetylserine L-cysteine NH2 10-acetylserines L-serine