What are the protein amino acids modified during N-linked glycosylation? What are the steps involved in the addition of the en masse carbohydrate complex to a protein and its modification in the ER?
n-linked glycolysation :
all the N_LINKED CARBOHYDRATES are linked through N-ACETYKGLUCOSAMINE and AMINO ACID ASPARGINE -it starts with addition of 14-sugar precursor with asparagine amino acid
-CARBOHYDRATES are attached to PROTIEN IN TWO WAYS :N_LINKEd and o-linked GLYCOLYSATIOM
carbohydrates are attached to protiens by nitrogen or oxygen.
MODIFICATION IN ER:
n-linked glycolysation begins in ER
path taken by polypeptide through secretary pathwat starts with its translocation across or into ER membrane.
it must be folded andmodified correctly in ER before being transported via golgi apparatusto cell surface and futher destinations.
What are the protein amino acids modified during N-linked glycosylation? What are the steps involved in...
5. Many proteins are glycosylated via 0- or N-linked sugars. Describe N-linked protein glycosylation and its processing. 3 marks
In glycoproteins, to what three amino acids are carbohydrate groups most frequently linked? To what functional group is the glycan linked in each case?
21. Which of the following would NOT change the structure and function of a protein A Methylation of a protein B. Lipid modification of a protein C Change in the length of the Poly A tail of the mRNA transcript encoding a protein D. Change in the position of reactive amino acids E. Proteolysis 22. Two peptides have almost the exact same primary structure, except that one has about 10 fewer amino acids at the amino-terminus (N-terminus) of the protein....
What would happen in each of the following cases? Assume in each case that the protein involved is a soluble protein, not a membrane protein. You add a signal sequence (for the ER) to the N-terminal end of a normally cytosolic protein. You change the hydrophobic amino acids in an ER signal sequence into charged amino acids. You change the hydrophobic amino acids in an ER signal sequence into other hydrophobic amino acids. You move the N-terminal ER signal sequence...
21: Met c aion of the Polamino 21. Which of the following would NOT Change the structure and function of a protein A Methylation of a protein B. Lipid modification of a protein C. Change in the length of the Poly A tail of the mRNA transcript encoding a protein D. Change in the position of reactive amino acids E. Proteolysis 22. Two peptides have almost the exact same primary structure, except that one has about 10 fewer amino acids...
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G alpha z (Gaz) is a protein of 355 amino acids in length. It is synthesized in the cytoplasm and has no signal sequence, nor a start-transfer sequence, nor a nuclear import sequence or patch. After its initial synthesis, Gaz is bound by another protein called a palmitoyltransferase, which covalently attaches a fatty acid called palmitate to a cysteine side chain near the N-terminus of Gaz. This lipid modification allows Gaz to associate with the inner face of the plasma...
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