Question

With the aid of a diagram, outline the synthesis and function of inflammatory mediators derived from phospholipids. Indicate in your diagram the target of anti-inflammatory and immunosuppressant drugs that affect lipid mediator signalling. (Pharmacology)

Answer 1

PAGE No. TE: CELL MEMBRANE PHOSPHO LIPIDS IN Phospholipase --X-.. Corticosteroids Arachidonic acid | Хіреузелам cycloxygenace (cox) - X- NSAID, AS A prostaglandins PGE &/PGI 2 / PGD2/PGE2) Leukotrienes LTB4 K4/D4) F4 Thromboxanes

# Production

Phospholipase enzyme cleaves the fatty acid arachidonic acid from the phospho lipid molecule. Later by the action of lipoxygenase and cycloxygenase it will be converted into leukotrenes and prostaglandins, thromboxanes respectively.

# Function

Prostaglandins; Synthsised in the wall of blood vessels. Its causes vasodilation. Through this function it acts as an inflammatory mediator.

Leukotrenes triggers the smooth muscle contraction in branchioles. Major cause for asthma.

# Inhibition

Corticosteroids inhibit the step catalysed by phospholipase and blocks the production of arachidonic acids.

NSAID ( Non steroidal anti inflammatory drugs) inhibits the prostaglandin production from arachidonic acid by blocking cycloxygenase activity.