Question

4) Use the questions below to help you briefly describe the process by which the parts of the 3rd line of defense would work together to target extracellular pollen. Be sure to provide a BRIEF 1 sentence explanation of each part’s function.

4a) What specific immune cells would be activated by the CD4+ T helper cells in response to an allergic response to pollen? How will these cells be used to inactivate the pollen?

CD4+ T helper cells will secrete IL-4 cytokines, which activates B cells. B cells become plasma cells and secrete antibodies to inactivate pollen. CD4+ T helper cells also activate mast cells and basophils. Mast cells inactivate pollen through phagocytosis, while basophils respond to the allergic reaction by releasing histamine to dilate bronchioles and counteract the effects of the pollen.

4b) What chemicals (list specific enzymes or antibodies: IgA, IgE, IgG, IgM) would be produced by the cells listed in question 4a? Assume that the pollen is OUTSIDE the cells within the respiratory tract.

**this is my guess so far. Is there anything else beside IgE for part B and any edits to part A?

Answer 1

For part (a) & part (6) Inhalation of pollen grain In airway frofessican Apes are present beneath the epithelial cells. Pullen allergen hesses the epithelial cells All like dendritic cell kinds the pallon to the MHC I moleule. Present this pollen grain toe naive Treell az Coucells Naive In cell differentiates into effector. The cells, sullores IL-4 cytokine. cytokines = JL-5, 11-134 IL-9 &t binds on the recebter bresent on Brell which leads to it's proliferationt differentiation, Further activation of to memory B cell plasmacelli Busophils , eosinopils - and mast cells. It kinds with high affinity to Fc recepter on the - mast cells 4 basophills histamine, proteoglycans, pratecolytic . [sentes enzymes & cytokines histormine + cytokines + Cyst Ts[wysteinyl leukobiere) along with prostaglandins. I cs Scales, I L-4, IL-5, IL-6. leads to the... leukotrienes. CamScanner Casinophil chemotanis!

Histamine is veleased by basophils & the mast cells which increases the permeability of the tapt capillanes to WBC like neutrophils, eosinophils, lymphocytes ? monocytes & basophils. Out of these monocytes, neutrophols Causs phagocytosis of pollen grains. » Mast cells also phagocytose the paller grain. so phagocytosis is the way to inactivate pollen grain. CamScanner

Since pollen causes allergy and in allergic reactions, only IgE is released.

Also to inactivate pollen grains phagocytosis occurs.

I have provided a flow chart for the cells involved and the chemicals released by them and how their activation occurs.