Question

How does the nucleophile approach the electrophilic center in an Sn2 reaction? From the same side as the leaving group opposite the electronegative leaving group The direction of the nucleophile's approach is not important

Answer 1

In Sp2 reaction the nucleephile approaches from the opposite side of the electronegative leaving group followed by Wolden inversion (inversion takes place if the leaving group attach to a Chiral carbon) R RI Nu S- Nürn ys LRAX R → Nu lehead Rz Rg 'R Backside attack R₂ T.5 possible in 302 The TS Inversion of the cloral centre. C Same side attack of the mudoophile is not because of the electrostatic ze fulsion bataseen two electrongaftice atom cause in the transition State, thus the energy of the increases & the SN2 becomes un unfavourable. electrostatic repulsion » X Ri & eNu Ĉ Nu RE R Pus R